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Titolo:
Localization of the presynaptic cytomatrix protein piccolo at ribbon and conventional synapses in the rat retina: Comparison with bassoon
Autore:
Dick, O; Hack, I; Altrock, WD; Garner, CC; Gundelfinger, ED; Brandstatter, JH;
Indirizzi:
Max Planck Inst Hirnforsch, Abt Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany Leibniz Inst NeurobiolMagdeburg Germany D-39118 9118 Magdeburg, Germany Univ Alabama, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 iv Alabama, Birmingham, AL 35294 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 439, anno: 2001,
pagine: 224 - 234
SICI:
0021-9967(20011015)439:2<224:LOTPCP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN RETINA; DIFFERENTIAL EXPRESSION; VERTEBRATE RETINA; CALCIUM CHANNELS; PLEXIFORM LAYER; BIPOLAR CELLS; ACTIVE ZONES; RECEPTOR; MEMBRANE; RELEASE;
Keywords:
synaptic proteins; glutamatergic; GABAergic and glycinergic synapses; immunocytochemistry; postembedding immunoelectron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Brandstatter, JH Max Planck Inst Hirnforsch, Abt Neuroanat, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Deutschordenstr46 Frankfurt Germany D-60528
Citazione:
O. Dick et al., "Localization of the presynaptic cytomatrix protein piccolo at ribbon and conventional synapses in the rat retina: Comparison with bassoon", J COMP NEUR, 439(2), 2001, pp. 224-234

Abstract

In recent years significant progress has been made in the elucidation of the molecular assembly of the postsynaptic density at synapses, whereas little is known as yet about the components of the presynaptic active zone. Piccolo and Bassoon, two structurally related presynaptic cytomatrix proteins,are highly concentrated at the active zones of both excitatory and inhibitory synapses in rat brain. In this study we used immunocytochemistry to examine the cellular and ultrastructural localization of Piccolo at synapses in the rat retina and compared it with that of Bassoon. Both proteins showedstrong punctate immunofluorescence in the outer and the inner plexiform layers of the retina. They were found presynaptically at glutamatergic ribbonsynapses and at conventional GABAergic and glycinergic synapses. Although the two proteins were coexpressed at all photoreceptor ribbon synapses and at some conventional amacrine cell synapses, at bipolar cell ribbon synapses only Piccolo was present. Our data demonstrate similarities but also differences in the molecular composition of the presynaptic apparatuses of the synapses in the retina, differences that may account for the functional differences observed between the ribbon and the conventional amacrine cell synapses and between the photoreceptor and the bipolar cell ribbon synapses inthe retina. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:06:31