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Titolo:
Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis
Autore:
Umemura, T; Kodama, Y; Hioki, K; Inoue, T; Nomura, T; Kurokawa, Y;
Indirizzi:
Natl Inst Hlth Sci, Biol Safety Res Ctr, Div Toxicol, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci, Cent Inst Expt Anim, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 t Expt Anim, Tokyo 1588501, Japan
Titolo Testata:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
fascicolo: 10, volume: 127, anno: 2001,
pagine: 583 - 590
SICI:
0171-5216(200110)127:10<583:B(ISOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-CELL LINES; BUTYLATED HYDROXYTOLUENE; MOUSE LUNG; 4-NITROQUINOLINE 1-OXIDE; TUMOR-DEVELOPMENT; VINYL CARBAMATE; INDUCTION; STRAIN; GENE; TUMORIGENESIS;
Keywords:
rasH2 mice; lung carcinogen; BHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Umemura, T Natl Inst Hlth Sci, Biol Safety Res Ctr, Div Toxicol, Setagaya Ku, 1-18-1 Kamiyoga, Tokyo 1588501, Japan Natl Inst Hlth Sci 1-18-1 Kamiyoga Tokyo Japan 1588501 , Japan
Citazione:
T. Umemura et al., "Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis", J CANC RES, 127(10), 2001, pp. 583-590

Abstract

Purpose: Transgenic mice carrying the human prototype c-Ha-ras gene (rasH2mice) are highly susceptible to lung carcinogens. In order to investigate the possibility of developing a rapid in vivo assay for lung carcinogens, we examined whether the tumor-promoting activity of butylhydroxytoluene (BHT) is efficacious in rasH2 mice. Methods: rasH2 mice and wild littermates ofboth genders were pre-treated with carcinogens [urethane (UR), 4-nitroquinoline 1-oxide (4NQO) or diethylnitrosamine (DEN)], and, one day later, given a 400 mg/kg dose of BHT. Results: Six weeks after the initiation treatment, evidence of carcinogenicity could be detected in male and female rasH2 mice that had received UR doses of greater than or equal to 250 mg/kg and greater than or equal to 125 mg/kg, respectively, prior to exposure to BHT, whereas only 500 mg/kg of UR was sufficient to induce tumors in female rasH2mice given the carcinogen alone. The carcinogenicity of 15 mg/kg of 4NQO could be detected after 9 weeks in male rasH2 mice given the carcinogen followed by BHT. Similarly, the carcinogenicity of 60 mg/kg of DEN could be detected after 9 weeks and 6 weeks, respectively, in male and female rasH2 mice given the carcinogen followed by BHT. No carcinogenicity could be demonstrated through the experimental period with doses of 4NQO or DEN given alone. Conclusions: These results indicate that BHT administration increases thesusceptibility of rasH2 mice to lung carcinogens, and suggest that the useof BHT in rasH2 mice might lead to the establishment of a rapid in vivo assay for lung carcinogens.

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Documento generato il 29/09/20 alle ore 19:27:25