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Titolo:
Modulation of catecholamine release by endogenous adenosine in the rat adrenal medulla
Autore:
Tseng, CJ; Chan, JYH; Lo, WC; Jan, CR;
Indirizzi:
Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan Kaohsiung Vet Gen Hosp Kaohsiung Taiwan 813 & Res, Kaohsiung 813, Taiwan
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 389 - 394
SICI:
1021-7770(200109)8:5<389:MOCRBE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRAINS RENIN RELEASE; NORADRENALINE RELEASE; NERVE-STIMULATION; ANGIOTENSIN-II; MEDIATED INHIBITION; CHROMAFFIN CELLS; PURINE COMPOUNDS; BRAIN-STEM; SECRETION; RECEPTORS;
Keywords:
adenosine; adrenal medulla; captopril; catecholamine; insulin; renin-angiotensin system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tseng, CJ Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, 386 Ta Chung 1st Rd, Kaohsiung 813, Taiwan Kaohsiung Vet Gen Hosp 386 Ta Chung 1st Rd Kaohsiung Taiwan 813
Citazione:
C.J. Tseng et al., "Modulation of catecholamine release by endogenous adenosine in the rat adrenal medulla", J BIOMED SC, 8(5), 2001, pp. 389-394

Abstract

Adenosine was shown to inhibit norepinephrine (NE) release from sympathetic nerve endings. The purpose of this study was to examine whether endogenous adenosine restrains NE and epinephrine release from the adrenal medulla. The effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl) xanthine (DPSPX), on epinephrine and NE release induced by intravenousadministration of insulin in conscious rats were examined. Plasma catecholamines were measured by HPLC with an electrochemical detector. DPSPX significantly increased plasma catecholamine in both control rats and rats treated with insulin. The effect of DPSPX on plasma catecholamine was significantly greater in rats treated with insulin. Additional experiments were performed in adrenalectomized rats to investigate the contribution of the adrenalmedulla to the effect of DPSPX on plasma catecholamine. The effect of DPSPX and insulin on epinephrine in adrenalectomized rats was significantly reduced compared with that of the controls. Finally, we tested whether endogenous adenosine restrains catecholamine secretion partially through inhibiting the renin-angiotensin system. The effect of DPSPX on plasma catecholaminein rats pretreated with captopril (an angiotensin-converting enzyme inhibitor) was reduced. These results demonstrate that under basal physiological conditions, endogenous adenosine tonically inhibits catecholamine secretionfrom the adrenal medulla, and this effect is augmented when the sympathetic system is stimulated. The effect of endogenous adenosine on catecholaminesecretion from the adrenal medulla is achieved partially through the inhibitory effect of adenosine on the renin-angiotensin system. Copyright (C) 2001 National Science Council, ROC and S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:49:16