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Titolo:
Genome and Hormones: Gender Differences in Physiology - Selected Contribution: Estrogen receptor-alpha antisense decreases brain estrogen receptor levels and affects ventilation in male and female rats
Autore:
Inamdar, SR; Eyster, KM; Schlenker, EH;
Indirizzi:
Univ S Dakota, Sch Med, Div Basic Biomed Sci, Vermillion, SD 57069 USA Univ S Dakota Vermillion SD USA 57069 iomed Sci, Vermillion, SD 57069 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1886 - 1892
SICI:
8750-7587(200110)91:4<1886:GAHGDI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SEX-DIFFERENCES; MESSENGER-RNA; PREOPTIC AREA; NEONATAL RATS; NR2D SUBUNIT; EXPRESSION; BEHAVIOR; BETA; GENE;
Keywords:
cortex; hypothalamus; brain stem; N-methyl-D-aspartic receptor; aspartic acid; body weight; length;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Schlenker, EH Univ S Dakota, Sch Med, Div Basic Biomed Sci, 414 E Clark St, Vermillion, SD 57069 USA Univ S Dakota 414 E Clark St Vermillion SD USA 57069 069 USA
Citazione:
S.R. Inamdar et al., "Genome and Hormones: Gender Differences in Physiology - Selected Contribution: Estrogen receptor-alpha antisense decreases brain estrogen receptor levels and affects ventilation in male and female rats", J APP PHYSL, 91(4), 2001, pp. 1886-1892

Abstract

We hypothesized that administration of an antisense oligodeoxynucleotide (ODN) to estrogen receptor (ER)-alpha mRNA decreases the ER protein in the neonatal rat brain, alters the sex-specific ventilatory responses to aspartic acid in rats, and counteracts the effects of testosterone proportionate (TP) in females. One-day-old rat pups were injected intraventricularly with vehicle, antisense ER ODN, or scrambled ODN control. Additional groups of females received TP or vehicle and one of the three treatments. Brain ER protein levels were decreased by 65% at 6 h and 35% at 24 h after antisense ODN. Aspartic acid decreased ventilation in all groups of weanling males and females except ER ODN-treated females and TP-vehicle-treated females. Aspartic acid decreased ventilation in all groups of adult females except those given TP and in males. Weanling ER ODN-treated rats were shorter and weighed less than controls. Only adult ER ODN-treated males exhibited these traits. Thus neonatal ER affects aspartic acid modulation of breathing and body growth in a sex-specific and developmental manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:31:49