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Titolo:
Genome and hormones: Gender differences in physiology - Invited review: Cardiovascular protective effects of 17 beta-estradiol metabolites
Autore:
Dubey, RK; Jackson, EK;
Indirizzi:
Univ Zurich Hosp, Dept Obstet & Gynecol, Clin Endocrinol, CH-8051 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8051 CH-8051 Zurich, Switzerland Univ Pittsburgh, Med Ctr, Ctr Clin Pharmacol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 armacol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 ept Med, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Pharmacol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 armacol, Pittsburgh, PA 15213 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1868 - 1883
SICI:
8750-7587(200110)91:4<1868:GAHGDI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ESTROGEN-RECEPTOR-BETA; RAT CAROTID-ARTERY; VASCULAR ENDOTHELIAL-CELLS; O-METHYLTRANSFERASE COMT; PROTEIN-KINASE ACTIVITY; FATTY-ACID-ESTERS; CATECHOL ESTROGENS; GENE-EXPRESSION; POSTMENOPAUSAL WOMEN;
Keywords:
estrone; methoxyestradiol; catecholestradiol; hydroxyestradiol; mitogenesis; menopause; vascular smooth muscle; endothelium; cardiac fibroblasts;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Dubey, RK Univ Zurich Hosp, Dept Obstet & Gynecol, Clin Endocrinol, D217,NORD-1,Frauenklin Str 10, CH-8051 Zurich, Switzerland Univ Zurich Hosp D217,NORD-1,Frauenklin Str 10 Zurich Switzerland CH-8051
Citazione:
R.K. Dubey e E.K. Jackson, "Genome and hormones: Gender differences in physiology - Invited review: Cardiovascular protective effects of 17 beta-estradiol metabolites", J APP PHYSL, 91(4), 2001, pp. 1868-1883

Abstract

17 beta -Estradiol (estradiol), the most abundant endogenous estrogen, affords cardiovascular protection. However, in a given cohort of postmenopausal women, estradiol replacement therapy provides cardiovascular protection in only a subset. The reasons for this variable action can only be understood once the mechanisms by which estradiol induces its cardiovascular protective effects are known. Because most biological effects of estradiol are mediated via estrogen receptors (ERs) and the heart and blood vessels contain both ER-alpha and ER-beta, the prevailing view is that ERs mediate estradiol-induced cardiovascular protection. However, recent findings that estradiol protects against vascular injury in arteries of mice lacking either ER-alpha or ER-beta seriously challenges this concept. Thus other non-ER mechanisms may be operative. Endogenous estradiol is enzymatically converted to several nonestrogenic metabolites, and some of these metabolites induce potent biological effects via ER-independent mechanisms. Therefore, it is conceivable that the cardiovascular protective effects of estradiol are mediated via its endogenous metabolites. On the basis of the evidence cited in this review, the cardiovascular protective effects of estradiol are both ER dependent and independent. The purpose of this article is to review the evidence regarding the cardiovascular protective effects of estradiol metabolites and to discuss the cellular, biochemical, and molecular mechanisms involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:16:29