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Titolo:
Genome and hormones: Gender differences in physiology - Invited review: Cell localization, physiology, and nongenomic actions of estrogen receptors
Autore:
Levin, ER;
Indirizzi:
Long Beach VA Med Ctr, Med Serv 111I, Div Endocrinol, Long Beach, CA 90822USA Long Beach VA Med Ctr Long Beach CA USA 90822 ol, Long Beach, CA 90822USA Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA Univ Calif IrvineIrvine CA USA 92717 ept Pharmacol, Irvine, CA 92717 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1860 - 1867
SICI:
8750-7587(200110)91:4<1860:GAHGDI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; HUMAN-BREAST-CANCER; NITRIC-OXIDE SYNTHASE; EPIDERMAL GROWTH-FACTOR; ER-BETA; PLASMA-MEMBRANE; LIGAND-BINDING; TARGETED DISRUPTION; TISSUE DISTRIBUTION; GENE-TRANSCRIPTION;
Keywords:
nuclear receptors; apoptosis; membrane receptors; steroid receptors; signal transduction; cell proliferation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Levin, ER Long Beach VA Med Ctr, Med Serv 111I, Div Endocrinol, 5901 E 7thSt, Long Beach, CA 90822 USA Long Beach VA Med Ctr 5901 E 7th St Long Beach CA USA 90822 USA
Citazione:
E.R. Levin, "Genome and hormones: Gender differences in physiology - Invited review: Cell localization, physiology, and nongenomic actions of estrogen receptors", J APP PHYSL, 91(4), 2001, pp. 1860-1867

Abstract

The existence of binding proteins for the female sex steroid, 17 beta -estradiol, has been known for almost 50 years. Presently, two estrogen receptors (ERs), ER-alpha- and ER-beta, have been cloned in mammals, and they are expressed in many cell types of metazoans. ERs act primarily as nuclear transcription factors, and this effect is enhanced by ligand binding. Emergingdata have identified a separate pool of receptors for this steroid in the plasma membrane, but the mechanisms of action and cellular functions of these proteins are just beginning to be defined. In this review, the known details of the nuclear and plasma membrane ER functions will be discussed. A particular focus will be to define the signaling pathways from the membrane that lead to important cell physiology effects of estrogen. The potential interactions of membrane ER with other local proteins will also be discussed, and the unique but often complementary roles of the receptor pools will be highlighted. These details may be of additional relevance to other steroid receptors, since there is evidence of their existence in the cell membrane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:17:35