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Titolo:
Genome and hormones: Gender differences in physiology - Historical perspectives: An abridged history of sex steroid hormone receptor action
Autore:
Fannon, SA; Vidaver, RM; Marts, SA;
Indirizzi:
Soc Womens Hlth Res, Washington, DC 20036 USA Soc Womens Hlth Res Washington DC USA 20036 Res, Washington, DC 20036 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1854 - 1859
SICI:
8750-7587(200110)91:4<1854:GAHGDI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL GLUCOCORTICOID RECEPTOR; HUMAN ESTROGEN-RECEPTOR; HEAT-SHOCK PROTEIN; PROGESTERONE-RECEPTOR; ANDROGEN RECEPTOR; ER-BETA; BINDING; MECHANISMS; COACTIVATORS; ANTAGONISTS;
Keywords:
estrogen; progesterone; androgen; coactivators; corepressors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Vidaver, RM Soc Womens Hlth Res, 1828 L St NW,Suite 625, Washington, DC 20036 USA Soc Womens Hlth Res 1828 L St NW,Suite 625 Washington DC USA 20036
Citazione:
S.A. Fannon et al., "Genome and hormones: Gender differences in physiology - Historical perspectives: An abridged history of sex steroid hormone receptor action", J APP PHYSL, 91(4), 2001, pp. 1854-1859

Abstract

The field of steroid hormone action is well established, although it is barely more than four decades old. Pivotal experiments in the late 1950s and 1960s showed that hormone-binding components exist within nuclei of target tissues and that steroid hormones act by regulating gene expression, ratherthan directly influencing enzymatic processes. The understanding that steroid hormone receptors interact with the general transcription machinery andalter chromatin structure came in the 1970s and 1980s, and details of thismechanism continue to be elucidated. In addition, the discovery of rapid cellular responses to steroid hormones has led to the identification of putative membrane-bound steroid receptors that act without affecting gene transcription. As noted in the recent Institute of Medicine report Exploring theBiological Contributions to Human Health: Does Sex Matter?, the effects ofsteroid hormones and defects in steroid hormone receptor action have a profound impact on human health and disease. Future research directives include the development of potent, selective steroid receptor modulators, the elucidation of nongenomic steroid hormone effects, and further exploration of hormone-genome interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:06:06