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Titolo:
Effects of hypoxia on alveolar fluid transport capacity in rat lungs
Autore:
Sakuma, T; Hida, M; Nambu, Y; Osanai, K; Toga, H; Takahashi, K; Ohya, N; Inoue, M; Watanabe, Y;
Indirizzi:
Kanazawa Med Univ, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinada Ishikawa Japan 9200293 Ishikawa 9200293, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1766 - 1774
SICI:
8750-7587(200110)91:4<1766:EOHOAF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID CLEARANCE; PULMONARY-EDEMA; AGONIST THERAPY; EPINEPHRINE; SHEEP; CATECHOLAMINES; HYPOTHERMIA; EXPRESSION; RESOLUTION;
Keywords:
catecholamine; fluid balance; alveolar epithelium; denopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sakuma, T Kanazawa Med Univ, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinada Ishikawa Japan 9200293 200293, Japan
Citazione:
T. Sakuma et al., "Effects of hypoxia on alveolar fluid transport capacity in rat lungs", J APP PHYSL, 91(4), 2001, pp. 1766-1774

Abstract

There is little information regarding the effect of hypoxia on alveolar fluid clearance capacity. We measured alveolar fluid clearance, lung water volume, plasma catecholamine concentrations, and serum osmolality in rats exposed to 10% oxygen for up to 120 h and explored the mechanisms responsible for the increase in alveolar fluid clearance. The principal results were 1)alveolar fluid clearance did not change for 48 h and then increased between 72 and 120 h of exposure to hypoxia; 2) although nutritional impairment during hypoxia decreased basal alveolar fluid clearance, endogenous norepinephrine increased net alveolar fluid clearance; 3) the changes of lung watervolume and serum osmolality were not associated with those of alveolar fluid clearance; 4) an administration of beta -adrenergic agonists further increased alveolar fluid clearance; and 5) alveolar fluid clearance returned to normal within 24 h of reoxygenation after hypoxia. In conclusion, alveolar epithelial fluid transport capacity increases in rats exposed to hypoxia. It is likely that a combination of endogenous norepinephrine and nutritional impairment regulates alveolar fluid clearance under hypoxic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:34:34