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Titolo:
Determination of regional ventilation and perfusion in the lung using xenon and computed tomography
Autore:
Kreck, TC; Krueger, MA; Altemeier, WA; Sinclair, SE; Robertson, HT; Shade, ED; Hildebrandt, J; Lamm, WJE; Frazer, DA; Polissar, NL; Hlastala, MP;
Indirizzi:
Univ Washington, Div Pulm & Crit Care Med, Dept Med, Seattle, WA 98195 USAUniv Washington Seattle WA USA 98195 Med, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA Mt Whisper Light Stat Consulting, Seattle, WA 98112 USA Mt Whisper Light Stat Consulting Seattle WA USA 98112 attle, WA 98112 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1741 - 1749
SICI:
8750-7587(200110)91:4<1741:DORVAP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY BLOOD-FLOW; BODY ORIENTATION; FRACTAL ANALYSIS; GAS-EXCHANGE; HETEROGENEITY; GRAVITY; CT; EMBOLIZATION; EXPANSION; HUMANS;
Keywords:
functional imaging; in vivo imaging; gas exchange; blood solubility; recirculation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hlastala, MP Univ Washington, Div Pulm & Crit Care Med, Dept Med, Box 356522, Seattle, WA 98195 USA Univ Washington Box 356522 Seattle WA USA 98195 WA 98195 USA
Citazione:
T.C. Kreck et al., "Determination of regional ventilation and perfusion in the lung using xenon and computed tomography", J APP PHYSL, 91(4), 2001, pp. 1741-1749

Abstract

We propose a model to measure both regional ventilation ((V) over dot) andperfusion ((Q) over dot) in which the regional radiodensity (RD) in the lung during xenon (Xe) washin is a function of regional (V) over dot (increasing RD) and (Q) over dot (decreasing RD). We studied five anesthetized, paralyzed, mechanically ventilated, supine sheep. Four 2.5-mm-thick computed tomography (CT) images were simultaneously acquired immediately cephalad to the diaphragm at end inspiration for each breath during 3 min of Xe breathing. Observed changes in RD during Xe washin were used to determine regional(V) over dot and (Q) over dot. For 16 mm(3), displayed more variance than (V) over dot: the coefficient of variance of (Q) over dot (CV(Q) over dot) = 1.58 +/- 0.23, the CV of (V) over dot (CV(V) over dot) = 0.46 +/- 0.07, and the ratio of CV(Q) over dot to CV(V) over dot = 3.5 +/- 1.1. CV(Q) over dot (1.21 +/- 0.37) and the ratio of CV(Q) over dot to CV(V) over dot (2.4 /- 1.2) were smaller at 1,000-mm(3) scale, but CV(V) over dot (0.53 +/- 0.09) was not, (V) over dot/(Q) over dot distributions also displayed scale dependence: log SD of (V) over dot and log SD of (Q) over dot were 0.79 +/- 0.05 and 0.85 +/- 0.10 for 16-mm(3) and 0.69 +/- 0.20 and 0.67 +/- 0.10 for1,000-mm(3) regions of lung, respectively. (V) over dot and (Q) over dot measurements made with CT and Xe also demonstrate vertically oriented and isogravitational heterogeneity, which are described using other methodologies. Sequential images acquired by CT during Xe breathing can be used to determine both regional (V) over dot and (Q) over dot noninvasively with high spatial resolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:42:23