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Titolo:
Fastigial nucleus-mediated respiratory responses depend on the medullary gigantocellular nucleus
Autore:
Xu, FD; Zhou, TR; Gibson, T; Frazier, DT;
Indirizzi:
Univ Kentucky, Dept Physiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 ept Physiol, Lexington, KY 40536 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1713 - 1722
SICI:
8750-7587(200110)91:4<1713:FNRRDO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEEP CEREBELLAR NUCLEI; RAT BRAIN-STEM; C-FOS; NEURONS; EXPRESSION; NEUROTOXICITY; LOCALIZATION; PROJECTIONS; STIMULATION; HYPERCAPNIA;
Keywords:
electrical stimulation; hypercapnia; kainic acid; double labeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, FD Univ Kentucky, Dept Physiol, 800 Rose St MS 507, Lexington, KY 40536 USA Univ Kentucky 800 Rose St MS 507 Lexington KY USA 40536 Y 40536 USA
Citazione:
F.D. Xu et al., "Fastigial nucleus-mediated respiratory responses depend on the medullary gigantocellular nucleus", J APP PHYSL, 91(4), 2001, pp. 1713-1722

Abstract

Electrical stimulation of the rostral fastigial nucleus (FNr) alters respiration via activation of local neurons. We hypothesized that this FNr-mediated respiratory response was dependent on the integrity of the nucleus gigantocellularis of the medulla (NGC). Electrical stimulation of the FNr in 15anesthetized and tracheotomized spontaneously breathing rats significantlyaltered ventilation by 35.2 +/- 11.0% (P < 0.01) with the major effect being excitatory (78%). This respiratory response did not significantly differfrom control after lesions of the NGC via bilateral microinjection of kainic or ibotenic acid (4.5 +/- 1.9%; P > 0.05) but persisted in sham controls. Eight other rats, in which horseradish peroxidase (HRP) solution was previously microinjected into the left NGC, served as non-stimulation controls or were exposed to either 15-min repeated electrical stimulation of the right FNr or hypercapnia for 90 min. Histochemical and immunocytochemical datashowed that the right FNr contained clustered HRP-labeled neurons, most ofwhich were double labeled with c-Fos immunoreactivity in both electricallyand CO2-stimulated rats. We conclude that the NGC receives monosynaptic FNr inputs and is required for fully expressing FNr-mediated respiratory responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:36:41