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Titolo:
Normovolemic hemodilution improves oxygen extraction capabilities in endotoxic shock
Autore:
Creteur, J; Sun, QH; Abid, O; De Backer, D; Van der Linden, P; Vincent, JL;
Indirizzi:
Free Univ Brussels, Erasme Univ Hosp, Dept Intens Care, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 are, B-1070 Brussels, Belgium
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1701 - 1707
SICI:
8750-7587(200110)91:4<1701:NHIOEC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-CELL DEFORMABILITY; SUPPLY DEPENDENCE; SKELETAL-MUSCLE; SEPTIC SHOCK; SEPSIS; HEMATOCRIT; FLOW; MICROCIRCULATION; DELIVERY;
Keywords:
sepsis; hypoxia; oxygen availability; dog experiment; tonometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Vincent, JL Free Univ Brussels, Erasme Univ Hosp, Dept Intens Care, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 Route Lennik Brussels Belgium B-1070 m
Citazione:
J. Creteur et al., "Normovolemic hemodilution improves oxygen extraction capabilities in endotoxic shock", J APP PHYSL, 91(4), 2001, pp. 1701-1707

Abstract

We studied the effects of normovolemic hemodilution on tissue oxygen extraction capabilities in a canine model of endotoxic shock. Eighteen anesthetized and mechanically ventilated dogs underwent normovolemic hemodilution with 6% hydroxyethyl starch solution to reach hematocrit (Het) levels around 40, 30, or 20% before the administration of 2 mg/kg of Escherichia coli endotoxin. Cardiac tamponade was then induced by repeated injections of normalsaline into the pericardial sac to reduce cardiac output and study whole body oxygen extraction capabilities. Whole body critical oxygen delivery waslower in the Hct 20% and 30% groups (8.4 +/- 0.4 and 10.4 +/- 0.7 ml.kg(-1).min(-1), respectively) than in the Hct 40% group (12.8 +/- 0.8 ml.kg(-1).min(-1)) (both P < 0.005). The whole body critical oxygen extraction ratio was higher in the Het 30% and 20% groups (49.1 +/- 8.2 and 55.2 +/- 4.6%, respectively) than in the Het 40% group (37.1 +/- 4.4 %) (both P < 0.05). Liver critical oxygen extraction ratio was also higher in the Het 30% and 20%groups than in the Het 40% group. The arterial lactate concentrations and the gradient between ileum mucosal PCO2 and arterial PCO2 were lower in theHct 20% and 30% groups than in the Hct 40% group. We conclude that, duringan acute reduction in blood flow during endotoxic shock in dogs, normovolemic hemodilution is associated with improved tissue perfusion and increasedoxygen extraction capabilities.

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Documento generato il 02/06/20 alle ore 23:54:04