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Titolo:
Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans
Autore:
Cui, J; Wilson, TE; Shibasaki, M; Hodges, NA; Crandall, CG;
Indirizzi:
Presbyterian Med Ctr, Inst Exercise & Environm Med, Dallas, TX 75231 USA Presbyterian Med Ctr Dallas TX USA 75231 vironm Med, Dallas, TX 75231 USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 r, Dept Internal Med, Dallas, TX 75390 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1679 - 1686
SICI:
8750-7587(200110)91:4<1679:BMOMSN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATIC EXERCISE; CARDIOVASCULAR-RESPONSES; CAROTID BAROREFLEX; ARTERIAL-PRESSURE; GROUP-III; INCREASES; HEART; AFFERENTS; BLOCKADE;
Keywords:
metaboreceptor; baroreflex sensitivity; heart rate; exercise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Crandall, CG Presbyterian Med Ctr, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA Presbyterian Med Ctr 7232 Greenville Ave Dallas TX USA 75231
Citazione:
J. Cui et al., "Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans", J APP PHYSL, 91(4), 2001, pp. 1679-1686

Abstract

To identify whether muscle metaboreceptor stimulation alters baroreflex control of muscle sympathetic nerve activity (MSNA), MSNA, beat-by-beat arterial blood pressure (Finapres), and electrocardiogram were recorded in 11 healthy subjects in the supine position. Subjects performed 2 min of isometric handgrip exercise at 40% of maximal voluntary contraction followed by 2.5min of posthandgrip muscle ischemia. During muscle ischemia, blood pressure was lowered and then raised by intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl, respectively. The slope of the relationship between MSNA and diastolic blood pressure was more negative (P < 0.001) during posthandgrip muscle ischemia (-201.9 +/- 20.4 units.beat(-1).mmHg(-1)) when compared with control conditions (- 142.7 +/- 17.3 units.beat(-1).mmHg(-1)). No significant change in the slope of the relationship between heart rate and systolic blood pressure was observed. However, both curves shifted during postexercise ischemia to accommodate the elevation in blood pressure and MSNA that occurs with this condition. These data suggest that the sensitivity of baroreflex modulation of MSNA is elevated by muscle metaboreceptor stimulation, whereas the sensitivity of baroreflex of modulate heartrate is unchanged during posthandgrip muscle ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:47:56