Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cellular adaptation to repeated eccentric exercise-induced muscle damage
Autore:
Stupka, N; Tarnopolsky, MA; Yardley, NJ; Phillips, SM;
Indirizzi:
McMaster Univ, Dept Kinesiol, Exercise Metab Res Grp, Hamilton, ON L8S 4K1, Canada McMaster Univ Hamilton ON Canada L8S 4K1 rp, Hamilton, ON L8S 4K1, Canada McMaster Univ, Dept Med Neurol & Rehabil, Hamilton, ON L8S 4K1, Canada McMaster Univ Hamilton ON Canada L8S 4K1 il, Hamilton, ON L8S 4K1, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1669 - 1678
SICI:
8750-7587(200110)91:4<1669:CATREE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; GENDER DIFFERENCES; INJURY; CALPAIN; CONTRACTIONS; PREVENTION; DISRUPTION; ESTRADIOL; RELEASE; BOUTS;
Keywords:
Z-disk streaming; inflammatory cells; proteolysis; gender-based difference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, SM McMaster Univ, Dept Kinesiol, Exercise Metab Res Grp, AB116 IWC,1280 Main St W, Hamilton, ON L8S 4K1, Canada McMaster Univ AB116 IWC,1280 Main St W Hamilton ON Canada L8S 4K1
Citazione:
N. Stupka et al., "Cellular adaptation to repeated eccentric exercise-induced muscle damage", J APP PHYSL, 91(4), 2001, pp. 1669-1678

Abstract

Eccentrically biased exercise results in skeletal muscle damage and stimulates adaptations in muscle, whereby indexes of damage are attenuated when the exercise is repeated. We hypothesized that changes in ultrastructural damage, inflammatory cell infiltration, and markers of proteolysis in skeletal muscle would come about as a result of repeated eccentric exercise and that gender may affect this adaptive response. Untrained male (n = 8) and female (n = 8) subjects performed two bouts (bout 1 and bout 2), separated by 5.5 wk, of 36 repetitions of unilateral, eccentric leg press and 100 repetitions of unilateral, eccentric knee extension exercises (at 120% of their concentric single repetition maximum), the subjects' contralateral nonexercised leg served as a control (rest). Biopsies were taken from the vastus lateralis from each leg 24 h postexercise. After bout 2, the postexercise force deficit and the rise in serum creatine kinase (CK) activity were attenuated. Women had lower serum CK activity compared with men at all times (P < 0.05), but there were no gender differences in the relative magnitude of theforce deficit. Muscle Z-disk streaming, quantified by using light microscopy, was elevated vs. rest only after bout 1 (P < 0.05), with no gender difference. Muscle neutrophil counts were significantly greater in women 24 h after bout 2 vs. rest and bout 1 (P < 0.05) but were unchanged in men. Muscle macrophages were elevated in men and women after bout 1 and bout 2 (P < 0.05). Muscle protein content of the regulatory calpain subunit remained unchanged whereas ubiquitin-conjugated protein content was increased after both bouts (P < 0.05), with a greater increase after bout 2. We conclude that adaptations to eccentric exercise are associated with attenuated serum CK activity and, potentially, an increase in the activity of the ubiquitin proteosome proteolytic pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:10:53