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Titolo:
Enhanced lung C-fiber responsiveness in sensitized adult guinea pigs exposed to chronic tobacco smoke
Autore:
Bergren, DR;
Indirizzi:
Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 d, Dept Biomed Sci, Omaha, NE 68178 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1645 - 1654
SICI:
8750-7587(200110)91:4<1645:ELCRIS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKE; SENSORY RECEPTORS; PASSIVE SMOKING; SUBSTANCE-P; CAPSAICIN; HYPERRESPONSIVENESS; STIMULATION; TACHYKININS; HISTAMINE; ASTHMA;
Keywords:
pulmonary; tracheal pressure; C fibers; rapidly adapting receptors; capsaicin; bradykinin; ovalbumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bergren, DR Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 ed Sci, Omaha, NE 68178 USA
Citazione:
D.R. Bergren, "Enhanced lung C-fiber responsiveness in sensitized adult guinea pigs exposed to chronic tobacco smoke", J APP PHYSL, 91(4), 2001, pp. 1645-1654

Abstract

Tobacco smoke (TS) exposure induces bronchoconstriction and increases airway secretions and plasma extravasation in certain sensitive individuals, particularly those with asthma. C-fiber activation also induces these effects. Although the mechanism by which chronic TS exposure induces airway dysfunction is not well understood, TS exposure may enhance C-fiber responsiveness. To investigate the effect of chronic TS exposure on C-fiber responsiveness to capsaicin and bradykinin, especially in atopic individuals, we exposed ovalbumin (OA)sensitized guinea pigs to TS (5 mg/l air, 30 min/day for 7 days/wk) or to compressed air. Nonsensitized guinea pigs were also exposed to either compressed air or TS. Beginning after 120 days of exposure, C fibers and rapidly adapting receptors (RARs) were challenged with capsaicin and bradykinin. TS exposure enhanced sensory receptor and airway responsiveness to both intravenous capsaicin and bradykinin challenge. C-fiber, RAR, and airway responsiveness to capsaicin challenge was greatest in OA-sensitized guinea pigs exposed to TS. OA alone induced capsaicin hyperresponsivenessat 5 Vg. Airway responsiveness to bradykinin was also greatest in OA-sensitized guinea pigs exposed to TS. OA alone enhanced C-fiber responsiveness to bradykinin at 5 and 10 mug. C-fiber activation by either agonist appeareddirect, whereas RAR activation appeared indirect. Therefore, a mechanism of airway hyperirritability induced by the combination of OA sensitization and chronic TS exposure may include hyperirritability of lung C fibers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:48:19