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Titolo:
Nitric oxide and neurally mediated regulation of skin blood flow during local heating
Autore:
Minson, CT; Berry, LT; Joyner, MJ;
Indirizzi:
Univ Oregon, Dept Exercise & Movement Sci, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 cise & Movement Sci, Eugene, OR 97403 USA Mayo Clin & Mayo Fdn, Dept Anesthesiol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 siol, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1619 - 1626
SICI:
8750-7587(200110)91:4<1619:NOANMR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; FOREARM SKIN; NOCICEPTIVE AFFERENTS; DIABETIC-PATIENTS; HAIRY SKIN; VASODILATATION; TEMPERATURE; DYSFUNCTION; NEUROPATHY; RESPONSES;
Keywords:
cutaneous vascular conductance; axon reflex; human; microvascular dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Minson, CT Univ Oregon, Dept Exercise & Movement Sci, 122 Esslinger Hall, Eugene, OR 97403 USA Univ Oregon 122 Esslinger Hall Eugene OR USA 97403 OR 97403 USA
Citazione:
C.T. Minson et al., "Nitric oxide and neurally mediated regulation of skin blood flow during local heating", J APP PHYSL, 91(4), 2001, pp. 1619-1626

Abstract

The mechanisms underlying the skin blood flow (SkBF) response to local heating are complex and poorly understood. Our goal was to examine the role ofaxon reflexes and nitric oxide (NO) in the SkBF response to a local heating protocol. We performed 40 experiments following a standardized heating protocol with different interventions, including blockade of the axon reflex (EMLA cream), antebrachial nerve blockade (0.5% bupivacaine injection), andNO synthase (NOS) inhibition (greater than or equal to 10 mM N-G-nitro-L-arginine methyl ester; microdialysis). Appropriate controls were performed to verify the efficacy of the various blocks. Values are expressed as a percentage of maximal SkBF (SkBF(max); 50 mM sodium nitroprusside). At the initiation of local heating, SkBF rose to an initial peak, followed by a brief nadir, and a secondary, progressive rise to a plateau. Axon reflex block decreased the initial peak from 75+3 to 32 +/- 2% SkBF(max) (P < 0.01 vs. control) but did not affect the plateau. NOS inhibition before and throughout local heating reduced the initial peak from 75 +/- 3 to 56 +/- 3% SkBF(max)(P < 0.01) and the plateau from 87 +/- 4 to 40 +/- 5%. NOS inhibition during axon reflex block did not further reduce the initial SkBF peak compared with axon reflex block alone. Antebrachial nerve block did not affect the local heating SkBF response. The primary finding of these studies is that there are at least two independent mechanisms contributing to the rise in SkBF during nonpainful local heating: a fast-responding vasodilator system mediated by the axon reflexes and a more slowly responding vasodilator system that relies on local production of NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:35:25