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Titolo:
Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats
Autore:
Jew, KN; Moore, RL;
Indirizzi:
Univ Colorado, Dept Kinesiol & Appl Physiol, Cardiovasc Inst, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 Cardiovasc Inst, Boulder, CO 80309 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1545 - 1554
SICI:
8750-7587(200110)91:4<1545:GIPROM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-ATP CHANNELS; HEAT-SHOCK RESPONSE; ISCHEMIA-REPERFUSION; INFARCT SIZE; GUINEA-PIG; VENTRICULAR MYOCYTES; METABOLIC RESPONSE; POTASSIUM CHANNELS; EXERCISE; CARDIOPROTECTION;
Keywords:
exercise; myocardial recovery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Jew, KN Univ Colorado, Dept Kinesiol & Appl Physiol, Cardiovasc Inst, Campus Box 354, Boulder, CO 80309 USA Univ Colorado Campus Box 354 Boulder CO USA 80309 er, CO 80309 USA
Citazione:
K.N. Jew e R.L. Moore, "Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats", J APP PHYSL, 91(4), 2001, pp. 1545-1554

Abstract

In this study, we sought to determine whether there was any evidence for the idea that cardiac ATP-sensitive K+ (K-ATP) channels play a role in the training-induced increase in the resistance of the heart to ischemia-reperfusion (I/R) injury. To do so, the effects of training and an K-ATP channel blocker, glibenclamide (Glib), on the recovery of left ventricular (LV) contractile function after 45 min of ischemia and 45 min of reperfusion were examined. Female Sprague-Dawley rats were sedentary (Sed; n = 18) or were trained (Tr; n = 17) for >20 wk by treadmill running, and the hearts from these animals used in a Langendorff-perfused isovolumic LV preparation to assess contractile function. A significant increase in the amount of 72-kDa class of heat shock protein was observed in hearts isolated from Tr rats. The I/R protocol elicited significant and substantial decrements in LV developedpressure (LVDP), minimum pressure (MP), rate of pressure development, and rate of pressure decline and elevations in myocardial Ca2+ content in both Sed and Tr hearts. In addition, I/R elicited a significant increase in LV diastolic stiffness in Sed, but not Tr, hearts. When administered in the perfusate, Glib (1 muM) elicited a normalization of all indexes of LV contractile function and reductions in myocardial Ca2+ content in both Sed and Tr hearts. Training increased the functional sensitivity of the heart to Glib because LVDP and MP values normalized more quickly with Glib treatment in the Tr than the Sed group. The increased sensitivity of Tr hearts to Glib is a novel finding that may implicate a role for cardiac K-ATP channels in thetraining-induced protection of the heart from I/R injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:18:35