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Titolo:
Postexercise muscle glycogen resynthesis in obese insulin-resistant Zuckerrats
Autore:
Bruce, CR; Lee, JS; Hawley, JA;
Indirizzi:
RMIT Univ, Sch Med Sci, Fac Life Sci, Exercise Metab Grp, Bundoora, Vic 3083, Australia RMIT Univ Bundoora Vic Australia 3083 Grp, Bundoora, Vic 3083, Australia
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 91, anno: 2001,
pagine: 1512 - 1519
SICI:
8750-7587(200110)91:4<1512:PMGRIO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
2 DIFFERENT INTENSITIES; INDUCED DIABETIC RATS; SKELETAL-MUSCLE; GLUCOSE-TRANSPORT; EXHAUSTING EXERCISE; TRANSGENIC MICE; GENE-EXPRESSION; SYNTHASE; METABOLISM; REPLETION;
Keywords:
glycogen synthase; GLUT-4; hexokinase; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Hawley, JA RMIT Univ, Sch Med Sci, Fac Life Sci, Exercise Metab Grp, POB 71, Bundoora, Vic 3083, Australia RMIT Univ POB 71 Bundoora Vic Australia 3083 ic 3083, Australia
Citazione:
C.R. Bruce et al., "Postexercise muscle glycogen resynthesis in obese insulin-resistant Zuckerrats", J APP PHYSL, 91(4), 2001, pp. 1512-1519

Abstract

We determined the effect of an acute bout of swimming (8 x 30 min) followed by either carbohydrate administration (0.5 mg/g glucose ip and ad libitumaccess to chow; CHO) or fasting (Fast) on postexercise glycogen resynthesis in soleus muscle and liver from female lean (ZL) and obese insulin-resistant (ZO) Zucker rats. Resting soleus muscle glycogen concentration ([glycogen]) was similar between genotypes and was reduced by 73 (ZL) and 63% (ZO) after exercise (P < 0.05). Liver [glycogen) at rest was greater in ZO than ZL (334 +/- 31 vs. 247 +/- 16 <mu>mol/g wet wt; P < 0.01) and fell by 44 and 94% after exercise (P < 0.05). The fractional activity of glycogen synthase (active/total) increased immediately after exercise (from 0.22 +/- 0.05 and 0.32 +/- 0.04 to 0.63 +/- 0.08 vs. 0.57 +/- 0.05; P < 0.01 for ZL and ZO rats, respectively) and remained elevated above resting values after 30 min of recovery. During this time, muscle [glycogen] in ZO increased 68% with CHO (P < 0.05) but did not change in Fast. Muscle [glycogen] was unchanged in ZL from postexercise values after both treatments. After 6 h recovery,GLUT-4 protein concentration was increased above resting levels by a similar extent for both genotypes in both fasted (similar to 45%) and CHO-supplemented (similar to 115%) rats. Accordingly, during this time CHO refeeding resulted in supercompensation in both genotypes (68% vs. 44% for ZL and ZO). With CHO, liver [glycogen] was restored to resting levels in ZL but remained at postexercise values for ZO after both treatments. We conclude that the increased glucose availability with carbohydrate refeeding after glycogen-depleting exercise resulted in glycogen supercompensation, even in the face of muscle insulin-resistance.

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Documento generato il 10/04/20 alle ore 15:25:38