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Titolo:
Changes in neurocognitive performance in a cohort of patients treated withHAART for 3 years
Autore:
Tozzi, V; Balestra, T; Galgani, S; Narciso, P; Sampaolesi, A; Antinori, A; Giulianelli, M; Serraino, I; Ippolito, G;
Indirizzi:
INMI Lazzaro Spallanzani, Div Infect Dis 4, I-00149 Rome, Italy INMI Lazzaro Spallanzani Rome Italy I-00149 t Dis 4, I-00149 Rome, Italy Psychol Serv, Rome, Italy Psychol Serv Rome ItalyPsychol Serv, Rome, Italy San Camillo Hosp, Dept Neurosci, Rome, Italy San Camillo Hosp Rome Italy an Camillo Hosp, Dept Neurosci, Rome, Italy Clin Dept, Rome, Italy Clin Dept Rome ItalyClin Dept, Rome, Italy IRCCS Lazzaro Spallanzani, Natl Inst Infect Dis, Dept Epidemiol, Rome, Italy IRCCS Lazzaro Spallanzani Rome Italy t Dis, Dept Epidemiol, Rome, Italy
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 1, volume: 28, anno: 2001,
pagine: 19 - 27
SICI:
1525-4135(20010901)28:1<19:CINPIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS DEMENTIA COMPLEX; ACTIVE ANTIRETROVIRAL THERAPY; CENTRAL-NERVOUS-SYSTEM; IMMUNODEFICIENCY-VIRUS-INFECTION; HIV-1-INFECTED PATIENTS; CEREBROSPINAL-FLUID; HIV-INFECTION; INHIBITORS; IMPAIRMENT;
Keywords:
AIDS dementia complex; HIV-1; highly active antiretroviral therapy; protease inhibitors; neurocognitive impairment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tozzi, V INMI Lazzaro Spallanzani, Div Infect Dis 4, Via Portuense 292, I-00149 Rome, Italy INMI Lazzaro Spallanzani Via Portuense 292 Rome Italy I-00149 ly
Citazione:
V. Tozzi et al., "Changes in neurocognitive performance in a cohort of patients treated withHAART for 3 years", J ACQ IMM D, 28(1), 2001, pp. 19-27

Abstract

Objectives: To describe changes in HIV-associated neurocognitive impairment in patients treated with highly active antiretroviral therapy (HAART) forat least 3 years. Methods: Prospective, observational study of comprehensive neuropsychologic (NP) testing, neurologic examination, and laboratory measures before HAART and after 6, 15 and 45 months of HAART, on 28 consecutive patients seen in our department since April 1996. Results: At baseline, 16 patients were neurocognitively impaired and 12 were not. Among the 16 impaired patients, 5 patients failed to meet the criteria for impairment after 6 months and 9 patients after both 15 and 45 months of HAART, respectively. Statistically significant improvements (p less than or equal to .01) were seen in two of six measures exploring the concentration and speed of mental processing, two of three measures exploring mental flexibility, in one of five measures exploring memory, and in two of two measures exploring fine motor functions. Unimpaired study subjects performed better than impaired ones in 10 of 17 measures at baseline, in eight of 17 after 6 months, in six of 17 after 15 months, and in seven of 17 after 45months of HAART. Conclusions: During the course of HAART, patients experienced a positive and sustained improvement in their neurocognitive performance. However, the presence of 7 of 16 (43.7%) patients with neurocognitive impairment, and the persistence of statistically significant differences in the neurocognitive performance between impaired and unimpaired patients after more than 3 years of HAART, suggests that ongoing HIV-related neurologic damage can occureven during potent antiretroviral treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:32:35