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Titolo:
Indinavir crystallization around the loop of Henle: Experimental evidence
Autore:
Dieleman, JP; Salahuddin, S; Hsu, YS; Burger, DM; Gyssens, IC; Sturkenboom, MCJM; Stricker, BHC; Kok, DJ;
Indirizzi:
EMCR, Pharmacoepidemiol Unit, Dept Epidemiol & Biostat, Rotterdam, Netherlands EMCR Rotterdam Netherlands Epidemiol & Biostat, Rotterdam, Netherlands EMCR, Dept Internal Med, Rotterdam, Netherlands EMCR Rotterdam Netherlands R, Dept Internal Med, Rotterdam, Netherlands EMCR, Dept Urol, Rotterdam, Netherlands EMCR Rotterdam NetherlandsEMCR, Dept Urol, Rotterdam, Netherlands Univ Nijmegen Hosp, Dept Clin Pharm, NL-6500 HB Nijmegen, Netherlands UnivNijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands EMCR, Dept Med Microbiol & Infect Dis, The Hague, Netherlands EMCR The Hague Netherlands crobiol & Infect Dis, The Hague, Netherlands Inspectorate Healthcare, The Hague, Netherlands Inspectorate Healthcare The Hague Netherlands e, The Hague, Netherlands
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 1, volume: 28, anno: 2001,
pagine: 9 - 13
SICI:
1525-4135(20010901)28:1<9:ICATLO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-RENAL-FAILURE; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-PROTEASE INHIBITOR; INFECTED PATIENTS; CRYSTALLURIA; PLASMA; NEPHROLITHIASIS; UROLITHIASIS; NEPHROPATHY; INDIVIDUALS;
Keywords:
HIV-protease inhibitor; Indinavir; crystallization; Loop of Henle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Stricker, BHC Erasmus Univ, Pharmacoepidemiol Unit, Dept Internal Med 2, Ctr Med, Room L-448,POB 2400, NL-3000 CA Rotterdam, Netherlands Erasmus UnivRoom L-448,POB 2400 Rotterdam Netherlands NL-3000 CA
Citazione:
J.P. Dieleman et al., "Indinavir crystallization around the loop of Henle: Experimental evidence", J ACQ IMM D, 28(1), 2001, pp. 9-13

Abstract

Objective: To determine the probable site of the nephron and the plasma indinavir (IDV) concentration at which intrarenal IDV crystallization occurs. Design: We performed in vitro crystallization experiments in IDV solutionssimulating conditions found in the nephron. Methods: To determine intrarenal IDV concentrations at which conditions inthe nephron allow crystallization, several concentrations of IDV basic solutions (0-800 mM) were titrated from pH 4.0 to higher pH values until crystals formed within 1 minute. Based on the combination of pH and ionic strength at which crystals formed, we determined the site of the nephron at whichthis combination was first attained. Based on the capacity for concentration at that site, we were able to measure the corresponding plasma IDV concentration. Results: Under conditions normally found at the proximal tubule (i.e., pH 6.7 and ionic strength of 200 mM), IDV crystallized at 200 mg/L. Under conditions applying to the loop of Henle, pH 7.4 and ionic strength of 200 mM, IDV crystallized at 125 mg/L, which would correspond to a plasma IDV concentration of 8 mg. Conclusions: IDV crystallization is most likely in the loop of Henle and may already start at plasma IDV concentrations as low as 8 mg/L. Increasing hydration does not reduce the risk of IDV crystallization in the loop of Henle but instead prevents IDV crystallization and aggregation in the lower urinary tract. It remains to be confirmed whether prevention of high IDV plasma concentrations will reduce the risk of IDV crystallization in the loop of Henle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:35:14