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Titolo:
Laminar analysis of inhibition in the gerbil primary auditory cortex
Autore:
Foeller, E; Vater, N; Kossl, M;
Indirizzi:
Univ Munich, Inst Zool, D-80333 Munich, Germany Univ Munich Munich Germany D-80333 h, Inst Zool, D-80333 Munich, Germany Univ Potsdam, Inst Biochem & Biol, Potsdam, Germany Univ Potsdam PotsdamGermany dam, Inst Biochem & Biol, Potsdam, Germany
Titolo Testata:
JARO
fascicolo: 3, volume: 2, anno: 2001,
pagine: 279 - 296
SICI:
1525-3961(200109)2:3<279:LAOIIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY RECEPTIVE-FIELDS; GABAERGIC INHIBITION; COLUMNAR ORGANIZATION; RESPONSE PROPERTIES; MOUSTACHED BAT; TUNING CURVES; FUNCTIONAL TOPOGRAPHY; INFERIOR COLLICULUS; CORTICAL-NEURONS; COCHLEAR NUCLEUS;
Keywords:
auditory cortex; inhibition; bicuculline; GABA; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Foeller, E Univ Munich, Inst Zool, Luisenstr 14, D-80333 Munich, Germany Univ Munich Luisenstr 14 Munich Germany D-80333 unich, Germany
Citazione:
E. Foeller et al., "Laminar analysis of inhibition in the gerbil primary auditory cortex", JARO, 2(3), 2001, pp. 279-296

Abstract

Physiological and immunocytochemical evidence indicates a layer-dependent organization of inhibitory circuits in the neocortex. To investigate the contribution of GABAergic inhibition to frequency tuning in the different cortical layers, we recorded single and multiple units in near-radial penetrations before and during iontophoretic application of the GABA(A)-receptor antagonist bicuculline in the auditory cortex of the lightly anesthetized gerbil. Bicuculline generally increased the spontaneous rate and enhanced and prolonged onset activity. Application of bicuculline often resulted in a shift of best frequency and a decrease of threshold (5.5 dB). A broadening ofthe frequency tuning evident by lower Q(40dB) values was observed in 63% of the units. In units with multipeaked tuning curves or clearly separated response areas, bicuculline application removed the inhibitory regions and created single-peaked tuning curves. The influence of bicuculline on the receptive field size was not significantly layer-specific but tended to be most pronounced in lavers V and VI. In layer VI we frequently found "silent" neurons that responded to sound only when GABAergic inhibition was antagonized. From the analysis of postembedding GABA immunocytochemistry, the proportion of GABAergic neurons was found to be maximal in layers I and V, and the number of GABAergic perisomatic puncta (axon terminals) on cell somata peaked in layer V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:02:59