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Titolo:
Response properties of the refractory auditory nerve fiber
Autore:
Miller, CA; Abbas, PJ; Robinson, BK;
Indirizzi:
Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA UnivIowa Iowa City IA USA 52242 ead & Neck Surg, Iowa City, IA 52242 USA Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA Univ IowaIowa City IA USA 52242 Pathol & Audiol, Iowa City, IA 52242 USA
Titolo Testata:
JARO
fascicolo: 3, volume: 2, anno: 2001,
pagine: 216 - 232
SICI:
1525-3961(200109)2:3<216:RPOTRA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTION-POTENTIAL RECORDINGS; ELECTRICAL-STIMULATION; PHYSIOLOGICAL-PROPERTIES; MONOPHASIC STIMULATION; COCHLEAR NERVE; CAT; MODEL; DEPENDENCE; MONOPOLAR; STIMULUS;
Keywords:
refractory period; action potential; electric stimulation; cochlear nerve; cochlear implant; evoked potentials; cat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, CA Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 21201PFP,200 Hawkins Dr, Iowa City, IA 52242 USA Univ Iowa Hosp & Clin 21201 PFP,200 Hawkins Dr Iowa City IA USA 52242
Citazione:
C.A. Miller et al., "Response properties of the refractory auditory nerve fiber", JARO, 2(3), 2001, pp. 216-232

Abstract

The refractory characteristics of auditory nerve fibers limit their ability to accurately encode temporal information. Therefore, they are relevant to the design of cochlear prostheses. It is also possible that the refractory property could be exploited by prosthetic devices to improve information transfer, as refractoriness may enhance the nerve's stochastic properties. Furthermore, refractory data are needed for the development of accurate computational models of auditory nerve fibers. We applied a two-pulse forward-masking paradigm to a feline model of the human auditory nerve to assess refractory properties of single fibers. Each fiber was driven to refractoriness by a single (masker) current pulse delivered intracochlearly. Propertiesof firing efficiency, latency, jitter, spike amplitude, and relative spread (a measure of dynamic range and stochasticity) were examined by exciting fibers with a second (probe) pulse and systematically varying the masker-probe interval (MPI). Responses to monophasic cathodic current pulses were analyzed. We estimated the mean absolute refractory period to be about 330 mus and the mean recovery time constant to be about 410 mus. A significant proportion of fibers (13 of 34) responded to the probe pulse with MPIs as short as 500 mus. Spike amplitude decreased with decreasing MPI, a finding relevant to the development of computational nerve-fiber models, interpretation of gross evoked potentials, and models of more central neural processing. A small mean decrement in spike jitter was noted at small MPI values. Sometrends (such as spike latency-vs-MPI) varied across fibers, suggesting that sites of excitation varied across fibers. Relative spread was found to increase with decreasing MPI values, providing direct evidence that stochastic properties of fibers are altered under conditions of refractoriness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:17:06