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Titolo:
Neutrophil functions of patients with vasculitis related to myeloperoxidase-specific anti-neutrophil antibody
Autore:
Suzuki, K;
Indirizzi:
NIID, Lab Biodef, NIH, Shinjuku Ku, Tokyo 8640, Japan NIID Tokyo Japan 8640 D, Lab Biodef, NIH, Shinjuku Ku, Tokyo 8640, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 2, volume: 74, anno: 2001,
pagine: 134 - 143
SICI:
0925-5710(200108)74:2<134:NFOPWV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; MPO-ANCA; POLYMORPHONUCLEAR LEUKOCYTES; RHEUMATOID-ARTHRITIS; MOLECULAR-CLONING; EPITOPE ANALYSIS; MICE DEFICIENT; GLOMERULONEPHRITIS; SYSTEM; LECT2;
Keywords:
activated neutrophils; vasculitis; myeloperoxidase; anti-neutrophil cytoplasmic antibody; MPO-ANCA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, K NIID, Lab Biodef, NIH, Shinjuku Ku, Toyama 1 Chome, Tokyo 8640, Japan NIID Toyama 1 Chome Tokyo Japan 8640 1 Chome, Tokyo 8640, Japan
Citazione:
K. Suzuki, "Neutrophil functions of patients with vasculitis related to myeloperoxidase-specific anti-neutrophil antibody", INT J HEMAT, 74(2), 2001, pp. 134-143

Abstract

Neutrophils are hypothesized to cause tissue damage resulting in the development of vasculitis and glomerulonephritis, although they are known to primarily take part in host defense functions. The infiltration of inflammatory cells, notably neutrophils and macrophages, is observed in the progression of vasculitis. Neutrophils with activated status and anti-neutrophil cytoplasmic antibodies (ANCAs), especially myeloperoxidase-specific (MPO)-ANCA,have been implicated in the development of vasculitis. The target moleculeof MPO-ANCA is a lysosomal enzyme MPO that usually acts to kill bacteria, viruses, and fungi and that causes damage to the tissue due to the toxicityof its product, hypochlorite (OCl-). To elucidate the role of MPO-ANCA in the progression of vasculitis, a set of MPO-peptide fragments has been developed, and the corresponding epitope site for the specific monoclonal and/or oligoclonal antibody resulting in vasculitis has been determined. Recently, some mouse models have been used for analyzing the correlation between MPO and MPO-ANCA in relation to damage of blood vessels followed by the development of vasculitis. This review focuses on the role of activated neutrophils in the development of vasculitis associated with MPO-ANCA and the target molecules of ANCA. In addition, the reactivities of ANCA and inflammatory cytokines involving leukocyte-derived chemotaxin 2 (LECT2) are also discussed. (C) 2001 The Japanese Society of Hematology

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:12:48