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Titolo:
Contributions of myeloperoxidase to proinflammatory events: More than an antimicrobial system
Autore:
Nauseef, WM;
Indirizzi:
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 flammat Program, Iowa City, IA 52242 USA Univ Iowa, Dept Med, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Iowa, Dept Med, Iowa City, IA 52242 USA Vet Adm Med Ctr, Iowa City, IA USA Vet Adm Med Ctr Iowa City IA USAVet Adm Med Ctr, Iowa City, IA USA
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 2, volume: 74, anno: 2001,
pagine: 125 - 133
SICI:
0925-5710(200108)74:2<125:COMTPE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; STIMULATED HUMAN-NEUTROPHILS; HUMAN ATHEROSCLEROTIC INTIMA; PEROXIDE-CHLORIDE SYSTEM; OXIDANT MEMBRANE INJURY; RAY CRYSTAL-STRUCTURE; LUNG-CANCER RISK; HYDROGEN-PEROXIDE; NITRIC-OXIDE; HYPOCHLOROUS ACID;
Keywords:
myeloperoxidase; atherosclerosis; myeloperoxidase deficiency; inflammation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Nauseef, WM Univ Iowa, Inflammat Program, 200 Hawkins Dr, Iowa City, IA 52242 USA Univ Iowa 200 Hawkins Dr Iowa City IA USA 52242 , IA 52242 USA
Citazione:
W.M. Nauseef, "Contributions of myeloperoxidase to proinflammatory events: More than an antimicrobial system", INT J HEMAT, 74(2), 2001, pp. 125-133

Abstract

Optimal oxygen-dependent antimicrobial activity of circulating polymorphonuclear leukocytes reflects the synergistic effects of the myeloperoxidase (MPO)-hydrogen peroxide-halide system. Delivered from its storage compartment to the phagolysosome during fusion of the azurophilic granules, MPO catalyzes the oxidation of chloride in the presence of H2O2, chemistry unique toMPO, and thereby generates an array of highly reactive oxidants. Recent investigations of a wide range of inflammatory disorders have identified biochemical markers of MPO-dependent reactions, thus indirectly implicating MPOin their pathogenesis, progression, or perpetuation. The implied involvement of MPO-dependent events in diseases such as atherosclerosis forces reexamination of several fundamental tenets about MPO that are derived from studies of myeloid cells, most notably factors important in the regulated expression of MPO gene transcription. The evidence supporting a role for MPO in the pathogenesis of atherosclerosis, demyelinating diseases of the central nervous system, and specific cancers is reviewed and some of the new questions raised by these studies are discussed. Lastly, an appreciation for the existence of a broad family of proteins structurally related to MPO and thefunctional diversity implied by the corresponding structures may provide insights into novel ways in which MPO can function as more than an importantantimicrobial component. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:23:37