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Titolo:
Dietary cholesterol enhances pulmonary eosinophilic inflammation in a murine model of asthma
Autore:
Yeh, YF; Huang, SL;
Indirizzi:
Natl Yang Ming Univ, Inst Environm Hlth Sci, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 ironm Hlth Sci, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Inst Publ Hlth, Taipei 112, Taiwan
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 4, volume: 125, anno: 2001,
pagine: 329 - 334
SICI:
1018-2438(200108)125:4<329:DCEPEI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERCHOLESTEROLEMIA; EXPRESSION; PREVALENCE; MONOCYTES;
Keywords:
asthma; cholesterol; interleukin-5; diet; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, SL Natl Yang Ming Univ, Inst Environm Hlth Sci, 155 Sec 2 Li Nong St, Taipei 112, Taiwan Natl Yang Ming Univ 155 Sec 2 Li Nong St Taipei Taiwan 112 iwan
Citazione:
Y.F. Yeh e S.L. Huang, "Dietary cholesterol enhances pulmonary eosinophilic inflammation in a murine model of asthma", INT A AL IM, 125(4), 2001, pp. 329-334

Abstract

Background. Epidemiological studies have suggested that the dietary pattern may be associated with the prevalence of asthma. We previously reported that an increased intake of foods of animal origin was associated with the occurrence of allergic rhinitis and asthma in adolescents. Here we examined the effect of dietary cholesterol in a murine model of allergic pulmonary inflammation. Methods: Weanling C57BL/6 mice were fed a control diet containing 0.02% cholesterol or a diet supplemented with 1% or 2% cholesterol. Four weeks later the mice were sensitized with intraperitoneal ovalbumin (OVA)followed by OVA or saline inhalation 2 weeks later. OVA aerosol-induced inflammation was significantly enhanced by dietary supplementation of 1% or 2% cholesterol. Results: Among OVA-challenged mice, leukocyte numbers, particularly those of eosinophils, in the bronchoalveolar space increased by 3- to 5-fold with the cholesterol supplement. Among OVA aerosol-challenged mice, the levels of interleukin-5 and cysteinyl leukotrienes in the bronchoalveolar lavage fluid were significantly higher in those fed the 2% cholesterol diet compared with mice on the control diet. Conclusions: Dietary cholesterol may enhance pulmonary allergic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:18:19