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Titolo:
Sensitizing capacity and residual allergenicity of hydrolyzed cow's milk formulae: Results from a murine model
Autore:
Niggemann, B; Nies, H; Renz, H; Herz, U; Wahn, U;
Indirizzi:
Humboldt Univ, Childrens Hosp, Charite, Dept Pediat Pneumol & Immunol, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 & Immunol, D-13353 Berlin, Germany Univ Marburg, Dept Clin Chem & Mol Diagnost, D-3550 Marburg, Germany Univ Marburg Marburg Germany D-3550 ol Diagnost, D-3550 Marburg, Germany
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 4, volume: 125, anno: 2001,
pagine: 316 - 321
SICI:
1018-2438(200108)125:4<316:SCARAO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOALLERGENIC INFANT FORMULAS; WHEY-PROTEIN HYDROLYSATE; FOOD ALLERGY; BOVINE-MILK; ANAPHYLACTIC REACTIONS; ANTIBODY-RESPONSES; ANTIGENIC ACTIVITY; IGE; IMMUNOGENICITY; HYPERSENSITIVITY;
Keywords:
allergy; cow's milk; food allergy; hydrolyzed formulae; murine model; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Niggemann, B Humboldt Univ, Childrens Hosp, Charite, Dept Pediat Pneumol &Immunol, Augustenburger Pl 1, D-13353 Berlin, Germany Humboldt Univ Augustenburger Pl 1 Berlin Germany D-13353 any
Citazione:
B. Niggemann et al., "Sensitizing capacity and residual allergenicity of hydrolyzed cow's milk formulae: Results from a murine model", INT A AL IM, 125(4), 2001, pp. 316-321

Abstract

Background: Cow's milk allergy is the most common cause of clinically relevant adverse reactions to food in infants and children. Partially and extensively hydrolyzed formulae are used for the therapy and prevention of cow'smilk allergy. However, the immunogenic potency of hydrolyzed cow's milk formulae to induce and/or enhance the allergic phenotype in vivo is still under debate. The aim of this study was to assess the sensitizing capacity andresidual allergenicity of various partially and extensively hydrolyzed cow's milk formulae in a murine model of cow's milk allergy. Methods: BALB/c mice were immunized with either a cow's milk formula or various partially and extensively hydrolyzed formulae. Immediate cutaneous hypersensitivity reactions and allergen-specific antibody production were assessed. Results:Although immunization with cow's milk resulted in 12/13 cases in a positive skin test response to intradermal injection of cow's milk formulae, only 1 mouse showed a positive skin test to one of the partially hydrolyzed formulae, and none showed positive reactions to other partially hydrolyzed formulae, any of the extensively hydrolyzed formulae, phosphate-buffered saline or the amino acid formula. However, 6 of 8 mice showed positive skin tests when immunized with partially hydrolyzed formulae and with one of the extensively hydrolyzed formulae. Conclusions: The residual allergenic potential is markedly reduced in many hydrolyzed formulae, but most of the formulae investigated could induce an allergic immune response in BALB/c mice. Our murine model seems to be suitable to investigate the sensitizing capacity of hydrolyzed formulae and to differentiate even between extensively hydrolyzed formulae. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 01/10/20 alle ore 15:19:18