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Titolo:
Allergy to dermatophagoides in a group of Spanish gypsies: Genetic restrictions
Autore:
Cardaba, B; Moffatt, MF; Fernandez, E; Jurado, A; Rojo, M; Garcia, M; Ansotegui, IJ; Cortegano, I; Arrieta, I; Etxenagusia, MA; del Pozo, V; Urraca, J; Aceituno, E; Gallardo, S; Palomino, P; Cookson, W; Lahoz, C;
Indirizzi:
Fdn Jimenez Diaz, Dept Immunol, E-28040 Madrid, Spain Fdn Jimenez Diaz Madrid Spain E-28040 ept Immunol, E-28040 Madrid, Spain Welcome Trust Ctr Human Genet, Asthma Genet Grp, Oxford, England Welcome Trust Ctr Human Genet Oxford England Genet Grp, Oxford, England Hosp Santiago Apostol, Dept Allergy, Vitoria, Spain Hosp Santiago ApostolVitoria Spain ostol, Dept Allergy, Vitoria, Spain Ctr Salud Sansomendi, Vitoria, Spain Ctr Salud Sansomendi Vitoria SpainCtr Salud Sansomendi, Vitoria, Spain
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 4, volume: 125, anno: 2001,
pagine: 297 - 306
SICI:
1018-2438(200108)125:4<297:ATDIAG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-E RESPONSES; T-CELL EPITOPES; FC-EPSILON-RI; SERUM IGE; LINKAGE ANALYSIS; IMMUNE-RESPONSE; HLA ANTIGENS; ASTHMA; BETA; MARKERS;
Keywords:
gypsies; Dermatophagoides allergy; HLA class II; Fc epsilon receptor (high-affinity IgE receptor); tumor necrosis factor; T cell receptor; genetic polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Lahoz, C Fdn Jimenez Diaz, Dept Immunol, Avda Reyes Catolicos 2, E-28040 Madrid, Spain Fdn Jimenez Diaz Avda Reyes Catolicos 2 Madrid Spain E-28040 ain
Citazione:
B. Cardaba et al., "Allergy to dermatophagoides in a group of Spanish gypsies: Genetic restrictions", INT A AL IM, 125(4), 2001, pp. 297-306

Abstract

Background. Spanish gypsies have traditionally lived as nomads, a reason why few epidemiological studies were done in this ethnic group. However, thehigh prevalence of asthmatic diseases demonstrated in a population residing in the North of Spain induces us to analyse whether it was due to the influence of genetic loci previously implicated in other population studies ascausing the disorders. Methods: DRB1* and DQB1* HLA class II, TCR-V alpha8.1, Fc epsilon RI-beta Rsa I exon 7 and intron 2, TNF-beta (LT alpha -Nco I) and CD14, were tested for association with asthma and atopy by multiple regression analysis, in 5 families comprising 87 individuals. Results: Significant associations were found with DQB1*02 (p = 0.02) and DQB1*0301 (p = 0.008) and elevated levels of total serum IgE. A negative association (p = 0.02) was found between total serum IgE and DRB1*14. Fc epsilon RI-beta Rsa I-In2 allele 1 was associated with high levels of total serum IgE (p = 0.04). Levels of Der p 1 IgE antibodies were negatively associated with DRB1*11-DQB1*0301 (p = 0.007), and positively with TCR V alpha -8 allele 1 (p = 0.04) and with Fc epsilon RI-beta Rsa I-In2 allele 1 (p = 0.009). Conclusions: Our results do not show any association between asthma and the genetic loci studied although they do suggest the existence of multiple genetic influences on the allergic response in these families. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 24/01/20 alle ore 16:34:20