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Titolo:
Oxygen consumption by lungs with acute and chronic injury in a rabbit model
Autore:
Fok, TF; Gu, GJS; To, KF; Xu, F; Ng, PC; Yin, J;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 9, volume: 27, anno: 2001,
pagine: 1532 - 1538
SICI:
0342-4642(200109)27:9<1532:OCBLWA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITICALLY ILL PATIENTS; BRONCHOPULMONARY DYSPLASIA; INDIRECT CALORIMETRY; CARDIAC-SURGERY; CARDIOPULMONARY BYPASS; PULMONARY FIBROSIS; FICK PRINCIPLE; GROWTH; INFANTS; VENTILATION;
Keywords:
oxygen consumption; lung; rabbit; animal; chronic lung injury; acute lung injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Fok, TF Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China R China
Citazione:
T.F. Fok et al., "Oxygen consumption by lungs with acute and chronic injury in a rabbit model", INTEN CAR M, 27(9), 2001, pp. 1532-1538

Abstract

Objective: To study the oxygen consumption by lungs with acquired acute and chronic injury in a rabbit model. Design: A non-randon-lized controlled animal study. Subjects and method: Three groups of White New Zealand rabbits were studied to determine the oxygen consumption of the lungs. Group 1 (n = 21, controls) consisted of healthy rabbits with normal lungs. The rabbits in group 2 (n = 14) had sustained acute lung damage induced by subcutaneous N-nitroso-N-methylurethane and those in group 3 (n = 9) had sustained chronic lung damage inflicted by a single dose of intra-tracheal bleomycin. Pulmonary oxygen consumption was estimated from the difference between the whole body oxygen consumption, measured by indirect calorimetry, and systemic oxygen consumption estimated by the Fick method. Measurements and results: Both acute and chronic lung-damaged groups had significantly greater pulmonary oxygen consumption than the control group, both as absolute values [control vs acute vs chronic: 0.25 (0.04) vs 0.76 (0.10) vs 1.77 (0.21) ml/kg per min, p < 0.001], and as a percentage of totalbody oxygen consumption [2.98 (0.47) vs 9.34 (1.39) vs 20.20 (2.11)%, p < 0.0001]. Histological evaluation of the severity of lung damage using a lung-injury score revealed significantly higher scores in both lung-injury groups than in the controls. Conclusions: These findings suggest that the lung is an important site of energy loss in subjects with acute and chronic lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:29:50