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Titolo:
The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: Mapping multipotent hematopoietic cell fate in intraembryonic mesoderm
Autore:
Tavian, M; Robin, C; Coulombel, L; Peault, B;
Indirizzi:
Hop Paul Brousse, INSERM, U506, F-94807 Villejuif, France Hop Paul Brousse Villejuif France F-94807 506, F-94807 Villejuif, France Inst Gustave Roussy, INSERM, U362, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France
Titolo Testata:
IMMUNITY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 487 - 495
SICI:
1074-7613(200109)15:3<487:THEBNI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CORD-BLOOD; NATURAL-KILLER-CELLS; IN-VITRO; PROGENITOR CELLS; MOUSE EMBRYO; BONE-MARROW; ENDOTHELIAL-CELLS; FETAL THYMUS; T-CELLS; B-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Tavian, M Hop Paul Brousse, INSERM, U506, F-94807 Villejuif, France Hop Paul Brousse Villejuif France F-94807 07 Villejuif, France
Citazione:
M. Tavian et al., "The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: Mapping multipotent hematopoietic cell fate in intraembryonic mesoderm", IMMUNITY, 15(3), 2001, pp. 487-495

Abstract

We have traced emerging hematopoietic cells along human early ontogeny by culturing embryonic tissue rudiments in the presence of stromal cells that promote myeloid and B cell differentiation, and by assaying T cell potential in the NOD-SCID mouse thymus. Hematogenous potential was present inside the embryo as early as day 19 of development in the absence of detectable CD34(+) hematopoietic cells, and spanned both lymphoid and myeloid lineages from day 24 in the splanchnopleural mesoderm and derived aorta where CD34(+)progenitors appear at day 27. By contrast, hematopoietic cells arising in the third week yolk sac, as well as their progeny at later stages, were restricted to myelopoiesis and therefore are unlikely to contribute to definitive hematopoiesis in man.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 12:49:37