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Titolo:
Intraembryonic, but not yolk sac hematopoietic precursors, isolated beforecirculation, provide long-term multilineage reconstitution
Autore:
Cumano, A; Ferraz, JC; Klaine, M; Di Santo, JP; Godin, I;
Indirizzi:
CNRS, Inst Embryol Cellulaire & Mol, FRE 2160, F-94736 Nogent Sur Marne, France CNRS Nogent Sur Marne France F-94736 0, F-94736 Nogent Sur Marne, France Coll France, F-94736 Nogent Sur Marne, France Coll France Nogent Sur Marne France F-94736 736 Nogent Sur Marne, France Inst Pasteur, Unite Dev Lymphocytes, URA 1961, CNRS, F-75724 Paris, FranceInst Pasteur Paris France F-75724 URA 1961, CNRS, F-75724 Paris, France Inst Pasteur, Unite Cytokines & Dev Lymphoide, F-75724 Paris, France Inst Pasteur Paris France F-75724 & Dev Lymphoide, F-75724 Paris, France
Titolo Testata:
IMMUNITY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 477 - 485
SICI:
1074-7613(200109)15:3<477:IBNYSH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY MOUSE EMBRYO; FETAL LIVER; STEM-CELLS; B-CELLS; CLASS-I; DIFFERENTIATION; EMERGENCE; EXPRESSION; SPLANCHNOPLEURA; GESTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Godin, I CNRS, Inst Embryol Cellulaire & Mol, FRE 2160, F-94736 Nogent SurMarne, France CNRS Nogent Sur Marne France F-94736 6 Nogent Sur Marne, France
Citazione:
A. Cumano et al., "Intraembryonic, but not yolk sac hematopoietic precursors, isolated beforecirculation, provide long-term multilineage reconstitution", IMMUNITY, 15(3), 2001, pp. 477-485

Abstract

The relative contribution of yolk sac and intraembryonic precursors to hematopoiesis has been a matter of long-standing controversy. As reconstitution activity has so far only been found in embryonic tissues after the onset of circulation, the origin of reconstituting cells could not be formally established. Here, we separated yolk sac and intraembryonic splanchnopleura prior to circulation and maintained the explants in organ culture before transfer. Precursors derived from the intraembryonic site generated multilineage hematopoietic progeny in adult mice for more than 6 months. Yolk sac cells only provided myeloid short-term reconstitution. The results reveal a differential hematopoietic capacity of precirculation embryonic tissues in vivo, and indicate that the only cells capable of adult long-term hematopoiesis are of intraembryonic origin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:16:49