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Titolo:
Comparative study of short-term anxiolytic potency of alprazolam and tandospirone in psychiatric outpatients with anxiety disorders
Autore:
Yamauchi, K; Yamada, S; Morita, K; Maeda, H; Tanaka, M;
Indirizzi:
Kurume Univ, Sch Med, Dept Neuropsychiat, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan Kurume Univ, Sch Med, Inst Brain Dis, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan Saga Med Sch, Dept Psychiat, Saga, Japan Saga Med Sch Saga JapanSaga Med Sch, Dept Psychiat, Saga, Japan
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 6, volume: 16, anno: 2001,
pagine: 469 - 473
SICI:
0885-6222(200108)16:6<469:CSOSAP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORADRENERGIC FUNCTION; PANIC DISORDER; FREE 3-METHOXY-4-HYDROXYPHENYLGLYCOL; DEXAMETHASONE SUPPRESSION; HEALTHY-SUBJECTS; SALIVA LEVEL; PLASMA MHPG; METABOLITES; CLONIDINE; THERAPY;
Keywords:
3-methoxy-4-hydroxyphenylglycol (MHPG); saliva; anxiety; alprazolam; tandospirone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Yamauchi, K Kurume Univ, Sch Med, Dept Neuropsychiat, Asahi Machi 67, Kurume, Fukuoka 8300011, Japan Kurume Univ Asahi Machi 67 Kurume Fukuoka Japan 8300011 Japan
Citazione:
K. Yamauchi et al., "Comparative study of short-term anxiolytic potency of alprazolam and tandospirone in psychiatric outpatients with anxiety disorders", HUM PSYCHOP, 16(6), 2001, pp. 469-473

Abstract

Anxiolytic potency of 1 week of treatment with alprazolam or tandospirone in psychiatric outpatients with anxiety disorders was evaluated by changes in the scores on the Hamilton Anxiety Scale and the State and Trait AnxietyInventory and in the saliva level of free-3-methoxy-4-hydroxyphenylglycol (free-MHPG). Saliva level of free-MHPG was significantly reduced by 1 week of treatment with alprazolam but not with tandospirone. Reductions in the HAS score after 1 week of drug treatment were greater in patients treated with alprazolam than in those treated with tandospirone. These results indicate that the short-term anxiolytic potency of alprazolam is greater than that of tandospirone and that the saliva level of MHPG would be a useful marker for the evaluation of the therapeutic potency of anxiolytic agents. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:28:05