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Titolo:
Fluvoxamine in obsessive-compulsive disorder: similar efficacy but superior tolerability in comparison with clomipramine
Autore:
Mundo, E; Rouillon, F; Figuera, ML; Stigler, M;
Indirizzi:
Univ Lisbon, Fac Med, Clin Psiquiatria, P-1699 Lisbon, Portugal Univ Lisbon Lisbon Portugal P-1699 Psiquiatria, P-1699 Lisbon, Portugal Ctr Addict & Mental Hlth, Clarke Div R30, Toronto, ON, Canada Ctr Addict &Mental Hlth Toronto ON Canada Div R30, Toronto, ON, Canada Hop Albert Chenevier, Psychiat Serv, Creteil, France Hop Albert ChenevierCreteil France ier, Psychiat Serv, Creteil, France Univ Lausanne, Dept Psychiat Adulte, Lausanne, Switzerland Univ Lausanne Lausanne Switzerland ychiat Adulte, Lausanne, Switzerland
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 6, volume: 16, anno: 2001,
pagine: 461 - 468
SICI:
0885-6222(200108)16:6<461:FIODSE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; CONTROLLED TRIAL; PHARMACOTHERAPY; MULTICENTER; METAANALYSIS; INHIBITORS; PLACEBO; SCALE;
Keywords:
fluvoxamine; clomipramine; obsessive-compulsive disorder; serotonin reuptake inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Figuera, ML Univ Lisbon, Fac Med, Clin Psiquiatria, Ave Prof Egas Moniz, P-1699 Lisbon, Portugal Univ Lisbon Ave Prof Egas Moniz Lisbon Portugal P-1699 rtugal
Citazione:
E. Mundo et al., "Fluvoxamine in obsessive-compulsive disorder: similar efficacy but superior tolerability in comparison with clomipramine", HUM PSYCHOP, 16(6), 2001, pp. 461-468

Abstract

Some meta-analyses have suggested that the selective serotonin reuptake inhibitors (SSRIs) are less effective than clomipramine in the treatment of obsessive-compulsive disorder (OCD). The aim of this double-blind, randomised, multicentre study was to directly compare the efficacy and safety of fluvoxamine and clomipramine in patients with OCD. A total of 227 patients were randomised to flexible doses of fluvoxamine or clomipramine (both 150-300mg/day) for 10 weeks. Fluvoxamine and clomipramine were both clinically effective and there were no statistically significant differences between thetwo treatment groups, at any visit, on the National Institute of Mental Health Obsessive-Compulsive global rating scale, the Yale-Brown Obsessive-Compulsive scale (total score and obsession and compulsion subscores), the Clinical Global Impression severity of illness and global improvement subscales, the Clinical Anxiety Scale and the 17-item Hamilton Depression Rating Scale. However, there were differences in safety between the two treatments. Compared with fluvoxamine-treated patients, those treated with clomipraminehad more anticholinergic side effects (dry mouth, constipation and tremor)and premature withdrawals due to adverse events (18 versus 9). The resultsfrom this controlled study indicate that fluvoxamine is as effective as clomipramine in the treatment of OCD but has a better tolerability profile. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:37:15