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Titolo:
Effect of sialyl Lewis(x) selectin blockade on myocardial protection during cardioplegic arrest and reperfusion
Autore:
Sauer, HH; Allen, SJ; Cox, CS; Laine, GA;
Indirizzi:
Univ Texas, Sch Med, Dept Anesthesiol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 , Dept Anesthesiol, Houston, TX 77030 USA Univ Texas, Sch Med, Dept Surg, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Sch Med, Dept Surg, Houston, TX 77030 USA Univ Texas, Sch Med, Ctr Microvasc & Lymphat Studies, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 & Lymphat Studies, Houston, TX 77030 USA Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 rmacol, College Stn, TX 77843 USA
Titolo Testata:
HEART SURGERY FORUM
fascicolo: 3, volume: 4, anno: 2001,
pagine: 216 - 222
SICI:
1098-3511(2001)4:3<216:EOSLSB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO-REFLOW PHENOMENON; P-SELECTIN; ISCHEMIA; INJURY; OLIGOSACCHARIDE; ADHESION; ISCHEMIA/REPERFUSION; FAMILY; HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sauer, HH Stadt Kliniken Oldenburg, Klin Herzchirurg, Dr Eden Str 10, D-26133 Oldenburg, Germany Stadt Kliniken Oldenburg Dr Eden Str 10 Oldenburg Germany D-26133
Citazione:
H.H. Sauer et al., "Effect of sialyl Lewis(x) selectin blockade on myocardial protection during cardioplegic arrest and reperfusion", HEART SUR F, 4(3), 2001, pp. 216-222

Abstract

Put-pose: Selectins play a crucial role in the neutrophil-mediated myocardial injury associated with ischemia/reperfusion. We investigated the effectof selectin inhibition on neutrophil-endothelial cell adhesion, myocardialwater content, and left ventricular (LV) recovery after cardiopulmonary bypass (CPB) and cardioplegia. Methods: Dogs were subjected to CPB and 60 minutes of hypothermic cardioplegia. A selectin inhibitor (SI) (25 mg/kg) was given five minutes prior to CPB and as a continuous infusion (5 mg/kg/h) throughout CPB (n = 6). Saline-treated controls (n = 6) received identical volumes. Preload recruitable stroke work (PRSW) was calculated by sonomicrometry and micromanometry Myocardial water content was determined by microgravimetry. Myeloperoxidase (MPO) activity was measured to quantify polymorphonuclear neutrophil (PMN) infiltration. Results: Sl did not attenuate PRSW as well as post-CPB MPO tissue activity. While we found no difference in myocardial water gain between groups 120 minutes post-CPB, there was better edema resolution with SLConclusions: Selectin antagonism does not reduce CPB-associated myocardialinjury, and contractile recovery is not enhanced.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:29:21