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Titolo:
Risk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers ofthe G20210A mutation of the prothrombin gene
Autore:
Santamaria, A; Mateo, J; Oliver, A; Menendez, B; Souto, JC; Borrell, M; Soria, JM; Tirado, I; Fontcuberta, J;
Indirizzi:
Hosp Santa Cruz & San Pablo, Dept Hematol, Thrombosis & Haemostasis Unit, Barcelona 08025, Spain Hosp Santa Cruz & San Pablo Barcelona Spain 08025 Barcelona 08025, Spain Fundacio Puigvert, Barcelona, Spain Fundacio Puigvert Barcelona SpainFundacio Puigvert, Barcelona, Spain
Titolo Testata:
HAEMATOLOGICA
fascicolo: 9, volume: 86, anno: 2001,
pagine: 965 - 971
SICI:
0390-6078(200109)86:9<965:ROTAWO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; DEEP-VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM; DEFICIENCIES; DEFECTS; MEMBERS; 20210A; USERS; EMET;
Keywords:
inherited thrombophilia; oral contraceptives; venous thromboembolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mateo, J Hosp Santa Cruz & San Pablo, Dept Hematol, Thrombosis & Haemostasis Unit, C Sant Antoni Ma Claret 167, Barcelona 08025, Spain Hosp Santa Cruz & San Pablo C Sant Antoni Ma Claret 167 Barcelona Spain 08025
Citazione:
A. Santamaria et al., "Risk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers ofthe G20210A mutation of the prothrombin gene", HAEMATOLOG, 86(9), 2001, pp. 965-971

Abstract

Background and Objectives. Oral contraceptives (OC) and inherited thrombophilia are well-known risk factors associated with venous thromboembolism (VTE). However, there are only few studies on the risk of WE in women with inherited thrombophilia who use oral contraceptives. Design and Methods. We performed a retrospective family cohort study of 325 women belonging to 97 families with inherited thrombophilia, including antithrombin, protein S and C deficiencies, the factor V Leiden mutation (FVL) and the G20210A mutation of the prothrombin gene (PT20210A) to determine the risk of WE associated with OC intake. Results. For carriers of the PT20210A mutation, the risk of VTE in OC users was 3-fold higher (95% CI 1.3-6.8) than that in non-carriers. Carriers ofFVL mutation taking OC showed an OR of 1.4 (95% CI 0.6-3.3), indicating a tendency to increased risk of VTE. Interpretation and Conclusions. Because of the high prevalence of the PT20210A (6.5%) and FVL (2%) mutations in the general Spanish population and the increased risk of VTE associated with OC intake, genetic screening for these mutations should be considered in potential OC users belonging to families with thrombophilia. (C) 2001, Ferrata Storti Foundation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:31:40