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Titolo:
Spontaneous remission of aplastic anemia: a retrospective analysis
Autore:
Lee, JH; Lee, JH; Shin, YR; Lee, JS; Kim, WK; Chi, HS; Park, CJ; Lee, KH;
Indirizzi:
Univ Ulsan, Dept Med, Coll Med, Asan Med Ctr,Songpa Ku, Seoul 138040, South Korea Univ Ulsan Seoul South Korea 138040 Songpa Ku, Seoul 138040, South Korea Univ Ulsan, Dept Clin Pathol, Coll Med, Asan Med Ctr, Seoul 138040, South Korea Univ Ulsan Seoul South Korea 138040 n Med Ctr, Seoul 138040, South Korea
Titolo Testata:
HAEMATOLOGICA
fascicolo: 9, volume: 86, anno: 2001,
pagine: 928 - 933
SICI:
0390-6078(200109)86:9<928:SROAAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED AGRANULOCYTOSIS; BONE-MARROW TRANSPLANTATION; GLOBULIN;
Keywords:
spontaneous remission; aplastic anemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JH Univ Ulsan, Dept Med, Coll Med, Asan Med Ctr,Songpa Ku, 388-1 Poongnap Dong, Seoul 138040, South Korea Univ Ulsan 388-1 Poongnap Dong Seoul South Korea 138040 uth Korea
Citazione:
J.H. Lee et al., "Spontaneous remission of aplastic anemia: a retrospective analysis", HAEMATOLOG, 86(9), 2001, pp. 928-933

Abstract

Background and Objectives. Although acquired aplastic anemia (AA) is usually a chronic disorder, a small proportion of patients with aplastic anemia has been reported to recover spontaneously without specific therapy such asallogeneic bone marrow transplantation or immunosuppressive treatment. We attempted to determine the rate of spontaneous remission in patients with AA. Design and Methods. We reviewed the medical records of adult patients (n=136) who were diagnosed as having aplastic anemia at the Asan Medical Centerfrom 1990 to 2000. The hematologic criteria of spontaneous remission were defined according to the proposed remission criteria of the SAA Working Party of the EBMTResults. Eighteen (13%) of 136 patients satisfied the criteria for spontaneous remission at a median of 14 days (range, 4-332) from the diagnosis of aplastic anemia. In fifteen (83%) of 18 patients, spontaneous remission occurred within 50 days, Spontaneous remission was complete in fourteen patients (78%). Only two patients relapsed at 208 and 1,857 days after spontaneous remission. Multivariate logistic regression analysis showed that the presence of infection at diagnosis (p = 0.017), a drug as an etiology of aplastic anemia (p = 0.028), and serum albumin level less than 3.4 g/dL (p = 0.005) were independent predictive factors for spontaneous remission. Interpretation and Conclusions. Our study confirmed that a minority of patients with AA recovered spontaneously. Spontaneous remission was rapid and complete in most patients, and relapses were rarely observed. in most caseswith spontaneous remission, aplastic anemia might associated with externalfactors such as a drug or infection. (C) 2001, Ferrata Storti Foundation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 16:00:04