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Titolo:
Prognostic factors and failure pattern in lymph node-negative stage IB andII cervical carcinoma treated with radical hysterectomy and postoperative irradiation
Autore:
Aoki, Y; Watanabe, M; Sasaki, M; Sato, T; Kase, H; Aida, H; Kurata, H; Tanaka, K;
Indirizzi:
Niigata Univ, Fac Med, Dept Obstet & Gynecol, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 tet & Gynecol, Niigata 9518510, Japan
Titolo Testata:
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
fascicolo: 1, volume: 52, anno: 2001,
pagine: 13 - 17
SICI:
0378-7346(2001)52:1<13:PFAFPI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GYNECOLOGIC-ONCOLOGY-GROUP; SQUAMOUS-CELL CARCINOMA; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; PELVIC RADIATION; RANDOMIZED TRIAL; CANCER; RADIOTHERAPY; CISPLATIN; METASTASIS;
Keywords:
cervical cancer; negative lymph nodes; radical hysterectomy; pelvic irradiation; prognostic factor; recurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Aoki, Y Niigata Univ, Fac Med, Dept Obstet & Gynecol, 1-757 Asahimachi Dori, Niigata 9518510, Japan Niigata Univ 1-757 Asahimachi Dori Niigata Japan9518510 0, Japan
Citazione:
Y. Aoki et al., "Prognostic factors and failure pattern in lymph node-negative stage IB andII cervical carcinoma treated with radical hysterectomy and postoperative irradiation", GYNECOL OBS, 52(1), 2001, pp. 13-17

Abstract

The aim was to determine the prognostic factors and recurrence pattern in stages IB and II cervical carcinoma patients with negative pelvic lymph nodes. 224 patients with stages IB and II cervical carcinoma underwent radicalhysterectomy (RH) from 1982 through 1995. Of 161 patients with negative lymph nodes, 65 patients received postoperative irradiation (RT) and 96 patients were given no further therapy according to surgical pathological findings. The overall 5-year disease-free survival was 94.1%. Two of 96 RH patients (2%) and 10 of 65 RH + RT patients (15%) had recurrence in pelvic and distant sites almost equally. Multivariate analysis revealed deep cervical invasion as the only independent prognostic factor. The 5-year disease-free survival was 98.8% for patients with shallow invasion and 85.8% for patientswith deep invasion (p < 0.0001). It is worthwhile to develop new strategies for the lymph node-negative patients with deep stromal invasion. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:03:45