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Titolo:
Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy
Autore:
Changani, KK; Jalan, R; Cox, IJ; Ala-Korpela, M; Bhakoo, K; Taylor-Robinson, SD; Bell, JD;
Indirizzi:
Hammersmith Hosp, Magnet Resonance Unit, MRC, Clin Sci Ctr,Imperial Coll,Sch Med, London W12 0NN, England Hammersmith Hosp London England W12 0NN Sch Med, London W12 0NN, England Hammersmith Hosp, Sch Med, Imperial Coll, Div Investigat Sci,Dept Imaging,London W12 0NN, England Hammersmith Hosp London England W12 0NN Imaging,London W12 0NN, England Hammersmith Hosp, Imperial Coll, Sch Med, Div Med Med A, London W12 0NN, England Hammersmith Hosp London England W12 0NN d Med A, London W12 0NN, England Univ Oxford, MRC, Biochem & Clin Magnet Resonance Unit, Dept Biochem, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU Dept Biochem, Oxford OX1 3QU, England
Titolo Testata:
GUT
fascicolo: 4, volume: 49, anno: 2001,
pagine: 557 - 564
SICI:
0017-5749(200110)49:4<557:EFAHGI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-CANCER PATIENTS; L-ALANINE INFUSION; HUMAN-LIVER; IN-VIVO; TURNOVER MEASUREMENTS; INSULIN-RESISTANCE; GLUCAGON-SECRETION; GLYCOGEN-CONTENT; P-31; METABOLISM;
Keywords:
gluconeogenesis; cirrhosis; alanine; ammonia; glucagon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor-Robinson, SD Hammersmith Hosp, Magnet Resonance Unit, MRC, Clin SciCtr,Imperial Coll,Sch Med, Du Cane Rd, London W12 0NN, England HammersmithHosp Du Cane Rd London England W12 0NN nd
Citazione:
K.K. Changani et al., "Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy", GUT, 49(4), 2001, pp. 557-564

Abstract

Background and aims-Alterations in gluconeogenesis in the diseased liver can be assessed non-invasively using magnetic resonance spectroscopy by measuring changes in phosphomonoester resonance which contains information regarding several metabolites, including the phosphorylated intermediates of the gluconeogenic pathway. Methods-P-31 magnetic resonance spectroscopy was used to determine changesin phosphomonoesters following bolus infusions of 2.8 mmol/kg L-alanine infive patients with functionally compensated cirrhosis and in five patientswith functionally decompensated cirrhosis. Results-Compared with six healthy volunteers, baseline phosphomonoester values were elevated by 35% (p <0.05) in the compensated cirrhosis group and by 57% (p <0.01) in the decompensated cirrhosis group. Following alanine infusion, phosphomonoesters in healthy volunteers increased by 46% from baseline values (p <0.01), in patients with compensated cirrhosis by 27% (p <0.02) but those with decompensated cirrhosis showed no increase from baseline. There was a reduction in the percentage of inorganic phosphate signal in all subjects. Conclusions-By analysing changes in phosphomonoester and inorganic phosphate resonances it is possible to discern clear metabolic differences betweenhealthy volunteers and patients with cirrhosis of varying severity using magnetic resonance spectroscopy. Those patients with functionally decompensated cirrhosis have higher percentage baseline phosphomonoester values but the absence of phosphomonoester elevation following L-alanine infusion suggests that they are unable to mount a significant metabolic response with a progluconeogenic stimulus.

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Documento generato il 02/07/20 alle ore 21:57:32