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Titolo:
Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacteriumtuberculosis
Autore:
Crick, DC; Mahapatra, S; Brennan, PJ;
Indirizzi:
Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA
Titolo Testata:
GLYCOBIOLOGY
fascicolo: 9, volume: 11, anno: 2001,
pagine: 107R - 118R
SICI:
0959-6658(200109)11:9<107R:BOTACO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEVALONATE-INDEPENDENT PATHWAY; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; CELL-WALL ARABINOGALACTAN; ESCHERICHIA-COLI; ISOPRENOID BIOSYNTHESIS; ISOPENTENYL DIPHOSPHATE; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE; NONMEVALONATE PATHWAY; 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL; ARABINOSYL RESIDUES;
Keywords:
arabinan; isopentenyl diphosphate; Myobacterium tuberculosis; peptidoglycan; polyprenyl phosphate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Crick, DC Colorado State Univ, Dept Microbiol, 200 W Lake St, Ft Collins, CO 80523 USA Colorado State Univ 200 W Lake St Ft Collins CO USA 80523 23 USA
Citazione:
D.C. Crick et al., "Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacteriumtuberculosis", GLYCOBIOLOG, 11(9), 2001, pp. 107R-118R

Abstract

The compositional complexity of the mycobacterial cell envelope differentiates Mycobacterium species from most other prokaryotes. Historically, research in this area has focused on the elucidation of the structure of the mycobacterial cell envelope with the result that the structures of the mycolicacid-arabinogalactan-peptidoglycan complex from M. tuberculosis are fairlywell understood. However, the current impetus for studying M. tuberculosisand other pathogenic mycobacteria is the need to identify targets for the development of new drugs. Therefore, emphasis has been shifting to the study of cell envelope biosynthesis and the identification of enzymes that are essential to the viability of M. tuberculosis. The publication of the complete M. tuberculosis genome in 1998 has greatly aided these studies. To date, thirteen enzymes involved in the synthesis of the arabinogalactan-peptidoglycan complex of M. tuberculosis have been identified and at least partially characterized. Eleven of these enzymes were reported subsequent to the publication of the M. tuberculosis genome, a clear indication of the rapid evolution of knowledge stimulated by the sequencing of the genome. In this article we review the current understanding of M. tuberculosis arabinogalactan-peptidoglycan structure and biosynthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 13:16:31