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Titolo:
Quantitative trait locus analysis in crosses between outbred lines with dominance and inbreeding
Autore:
Perez-Enciso, M; Fernando, RL; Bidanel, JP; Le Roy, P;
Indirizzi:
INRA, Stn Ameliorat Genet Animaux, F-31326 Castanet Tolosan, France INRA Castanet Tolosan France F-31326 x, F-31326 Castanet Tolosan, France Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 Univ, Dept Anim Sci, Ames, IA 50011 USA INRA, Genet Quantitat & Appl Stn, F-78352 Jouy En Josas, France INRA JouyEn Josas France F-78352 ppl Stn, F-78352 Jouy En Josas, France
Titolo Testata:
GENETICS
fascicolo: 1, volume: 159, anno: 2001,
pagine: 413 - 422
SICI:
0016-6731(200109)159:1<413:QTLAIC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG CHROMOSOME-4; POPULATION; INTERCROSS; FATNESS; GROWTH; QTL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Perez-Enciso, M INRA, Stn Ameliorat Genet Animaux, BP 27, F-31326 CastanetTolosan, France INRA BP 27 Castanet Tolosan France F-31326 olosan, France
Citazione:
M. Perez-Enciso et al., "Quantitative trait locus analysis in crosses between outbred lines with dominance and inbreeding", GENETICS, 159(1), 2001, pp. 413-422

Abstract

We provide a theoretical framework for quantitative trait locus (QTL) analysis of a crossed population where parental lines may be outbred and dominance as well as inbreeding are allowed for. It can be applied to any pedigree. A biallelic QTL is assumed, and the QTL allele frequencies can be different in each breed. The genetic covariance between any two individuals is expressed as a nonlinear function of the probability of up to 15 possible identity modes and of the additive and dominance effects, together with the allelic frequencies in each of the two parental breeds. The probabilities of each identity mode are obtained at the desired genome positions using a Monte Carlo Markov chain method. Unbiased estimates of the actual genetic parameters are recovered in a simulated F-2 cross and in a six-generation complex pedigree under a variety, of genetic models (allele fixed or segregatingin the parental populations and additive or dominance action). Results from analyzing an F-2 cross between Meishan and Large White pigs are also presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:44:16