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Titolo:
EFFICACY OF A SUBCUTANEOUSLY ADMINISTERED, ULTRAVIOLET LIGHT-KILLED PASTEURELLA-MULTOCIDA A-3-CONTAINING BACTERIN AGAINST TRANSTHORACIC CHALLENGE EXPOSURE IN GOATS
Autore:
PURDY CW; STRAUS DC; AYERS JR;
Indirizzi:
USDA ARS,CONSERVAT & PROD RES LAB,PO DRAWER 10 BUSHLAND TX 79012 TEXAS TECH UNIV,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL LUBBOCK TX 79430 TEXAS A&M UNIV,TEXAS VET MED DIAGNOST LAB AMARILLO TX 79106
Titolo Testata:
American journal of veterinary research
fascicolo: 8, volume: 58, anno: 1997,
pagine: 841 - 847
SICI:
0002-9645(1997)58:8<841:EOASAU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOWL CHOLERA; HAEMOLYTICA; PNEUMONIA; CALVES; VACCINE; CATTLE; MODEL; IDENTIFICATION; PROTECTION; SEROTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Purdy et al., "EFFICACY OF A SUBCUTANEOUSLY ADMINISTERED, ULTRAVIOLET LIGHT-KILLED PASTEURELLA-MULTOCIDA A-3-CONTAINING BACTERIN AGAINST TRANSTHORACIC CHALLENGE EXPOSURE IN GOATS", American journal of veterinary research, 58(8), 1997, pp. 841-847

Abstract

Objective-To determine the effectiveness of Pasteurella multocida biovar A, serovar 3 (Pm A:3) killed by exposure to UV light and incorporated with a polyacrylate bead carrier as a vaccine. Animals-18 weanlingmale Spanish goats. Procedure-Prospective, randomized controlled study with 3 treatment groups: positive-control (PC), negative-control (NC), and principal Pm A:3 bacterin (PA) groups. Six PC goats each received live Pm A:3 and polyacrylate beads twice, 22 days apart, by transthoracic injection into the left lung. Six NC goats each received only PA beads twice, 22 days apart, by transthoracic injection. Six principal goats each received Pm A:3 vaccine SC twice, 22 days apart. Fourteendays after the second vaccination, ail goats were challenge exposed with live Pm A:3 by transthoracic injection into the right lung, and 4 days later they were euthanatized and necropsied. Results-Mean volume of consolidated lung tissue at the challenge site was 1.75 cm(3) for the PC group, 15.18 cm(3) for the NC group, and 3.9 cm(3) for the PA vaccine group. The NC group had a significantly (P less than or equal to0.002) larger mean volume of consolidated lung tissue than did the PCand PA groups after challenge exposure. Conclusions-The PA bacterin and the PC groups developed protective immunity against live Pm A:3 challenge exposure. An SC administered, UV light-killed, Pm A:3 bacterin induced protective immunity similar to that induced by virulent live Pm A:3 injected into the target organ, the lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:06:23