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Titolo:
The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancyin vivo
Autore:
Natarajan, L; Witwer, NE; Eisenmann, DM;
Indirizzi:
Univ Maryland Baltimore Cty, Dept Biol Sci, Baltimore, MD 21250 USA Univ Maryland Baltimore Cty Baltimore MD USA 21250 altimore, MD 21250 USA
Titolo Testata:
GENETICS
fascicolo: 1, volume: 159, anno: 2001,
pagine: 159 - 172
SICI:
0016-6731(200109)159:1<159:TDCEBP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOX GENE-EXPRESSION; TUMOR-SUPPRESSOR PROTEIN; C-ELEGANS; CELL-MIGRATION; DESMOSOMAL PLAQUE; MULTIGENE FAMILY; POLARITY SIGNALS; EMBRYONIC HEART; MAP KINASE; WNT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenmann, DM Univ Maryland Baltimore Cty, Dept Biol Sci, 1000 Hilltop Cir, Baltimore, MD 21250 USA Univ Maryland Baltimore Cty 1000 Hilltop Cir Baltimore MD USA 21250
Citazione:
L. Natarajan et al., "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancyin vivo", GENETICS, 159(1), 2001, pp. 159-172

Abstract

beta -Catenins function both in cell adhesion as part of the cadherin/catenin complex and in Writ signal transduction as transcription factors. Vertebrates express two related proteins, beta -catenin and plakoglobin, while Drosophila has a single family member, Armadillo. Caenorhabditis elegans expresses three beta -catenin-related proteins, BAR-1, HMP-2, and WRM-1, whichare quite diverged sequence from each other and other beta -catenins. While BAR-1 and WRM-1 are known to act in Wnt-mediated processes, and HMP-2 acts in a complex with cadherin/alpha -catenin homologs, it is unclear whetherall three proteins retain the other functions of beta -catenin. Here we show that BAR-1, like vertebrate beta -catenin, has redundant transcription activation domains in its amino- and carboxyl-terminal regions but that HMP-2 and WRM-1 also possess the ability to activate transcription. We show viayeast two-hybrid analysis that these three proteins display distinct patterns of protein interactions. Surprisingly, we find that both WRM-1 and HMP-2 can substitute for BAR-1 in C. elegans when expressed from the bar-1 promoter. Therefore, although their mutant phenotypes and protein interaction patterns strongly suggest that the functions of beta -catenin in other species have been segregated among three diverged proteins in C. elegans, these proteins still retain sufficient similarity to display functional redundancy in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:59:26