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Titolo:
Changes in vascular alpha1-and alpha2-adrenoceptor responsiveness by selegiline treatment
Autore:
Pelat, M; Verwaerde, P; Tran, MA; Berlan, M; Senard, JM; Montastruc, JL;
Indirizzi:
Fac Med Toulouse, Lab Pharmacol Med & Clin, INSERM, U 317, F-31073 Toulouse 7, France Fac Med Toulouse Toulouse France 7 RM, U 317, F-31073 Toulouse 7, France Fac Med Toulouse, Ctr Midi Pyrenees Pharmacovigilance Pharmacoepide, F-31073 Toulouse, France Fac Med Toulouse Toulouse France F-31073 epide, F-31073 Toulouse, France
Titolo Testata:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 239 - 245
SICI:
0767-3981(200108)15:4<239:CIVAAR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; L-DEPRENYL; ORTHOSTATIC HYPOTENSION; BLOOD-PRESSURE; DOG; PHARMACOLOGY; MORTALITY; SUPERSENSITIVITY; SELECTIVITY; ANTAGONIST;
Keywords:
alpha 1-adrenoceptor; responsiveness; alpha2-adrenoceptor responsiveness; noradrenaline; selegiline; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Montastruc, JL Fac Med Toulouse, Lab Pharmacol Med & Clin, INSERM, U 317, 37 Allees JulesGuesde,BP 72002, F-31073 Toulouse 7, France Fac Med Toulouse37 Allees Jules Guesde,BP 72002 Toulouse France 7
Citazione:
M. Pelat et al., "Changes in vascular alpha1-and alpha2-adrenoceptor responsiveness by selegiline treatment", FUN CL PHAR, 15(4), 2001, pp. 239-245

Abstract

Pharmacoepidemiological studies have reported an excess of mortality with selegiline, a MAO B inhibitor used in the treatment of Parkinson's disease. The mechanism of this putative adverse effect remains unknown but an interaction with the sympathetic nervous system was suggested. The aim of the present study was to investigate the influence of selegiline (10 mg/daily, orally during one week) on vascular alpha1- and alpha2-adrenoceptor responsiveness in conscious unrestrained dogs. Selegiline significantly increased resting values of both systolic and diastolic blood pressures and noradrenaline plasma levels (HPLC without changing heart rate. Moreover, spectral analysis of systolic blood pressure (Fast Fourier Transformation) showed that selegiline increased the relative energy of a low frequency band without modifying the total spectrum. ED 50 calculated from dose-pressor response curves with phenylephrine (after beta-blockade by propranolol), an index of alpha1-adrenoceptor response or with noradrenaline (after alpha1- and beta blockade by prazosin plus propranolol), an index of alpha2-adrenoceptor response, were significantly higher after selegiline. Selegiline failed to modifythe number of platelet alpha2-adrenoceptors measured by [H-3] RX 821002 binding. Yohimbine-induced increase in noradrenaline release was significantly more marked after selegiline. These results support the evidence that selegiline induces a vascular alpha1- and alpha2-adrenoceptor-hyposensitivity that can be explained by the increase in noradrenaline release elicited by the drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:35:51