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Titolo:
Effects of the atypical antipsychotic risperidone on hostility and aggression in schizophrenia: a meta-analysis of controlled trials
Autore:
Aleman, A; Kahn, RS;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat, NL-3508 GA Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Dept Psychon, Psychol Lab, NL-3584 CS Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CS 3584 CS Utrecht, Netherlands
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 11, anno: 2001,
pagine: 289 - 293
SICI:
0924-977X(200108)11:4<289:EOTAAR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; HALOPERIDOL; VIOLENT; MANAGEMENT; EFFICACY; BEHAVIOR; DEMENTIA; PLACEBO;
Keywords:
atypical antipsychotics; risperidone; schizophrenia; aggression; hostility; meta-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kahn, RS Univ Utrecht, Med Ctr, Dept Psychiat, A 01-126,POB 85500, NL-3508GA Utrecht, Netherlands Univ Utrecht A 01-126,POB 85500 Utrecht Netherlands NL-3508 GA s
Citazione:
A. Aleman e R.S. Kahn, "Effects of the atypical antipsychotic risperidone on hostility and aggression in schizophrenia: a meta-analysis of controlled trials", EUR NEUROPS, 11(4), 2001, pp. 289-293

Abstract

Atypical antipsychotics have been hypothesized to be more effective than classical antipsychotics in the treatment of hostility and aggression, due to their characteristic pharmacological profile, involving serotonergic as well as dopaminergic systems. In the present quantitative review the published evidence regarding the effects of risperidone on hostility and aggression in schizophrenia is evaluated. Meta-analysis of seven controlled trials revealed significant differences between risperidone and classical antipsychotics and between risperidone and placebo, although the effect size was small. Additional analyses in which only methodological rigorous studies were included showed highly significant differences (risperidone versus classical antipsychotics) and the effect size approached the 'medium' range. We conclude that risperidone is superior to classical antipsychotics and placebo in the treatment of hostility and aggression in schizophrenia. Neuropharmacological mechanisms that might account for this effect are discussed, and directions for future research are outlined. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:02:53