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Titolo:
The systemic effects of intermittent claudication are reversed by angioplasty
Autore:
Lewis, DR; Day, A; Jeremy, JY; Baird, RN; Smith, FCT; Lamont, PM;
Indirizzi:
Univ Bristol, Bristol Royal Infirm, Dept Surg, Bristol BS8 1TH, Avon, England Univ Bristol Bristol Avon England BS8 1TH Bristol BS8 1TH, Avon, England Bristol Royal Infirm & Gen Hosp, Dept Chem Pathol, Bristol, Avon, England Bristol Royal Infirm & Gen Hosp Bristol Avon England stol, Avon, England Bristol Royal Infirm & Gen Hosp, Bristol Heart Inst, Bristol, Avon, England Bristol Royal Infirm & Gen Hosp Bristol Avon England stol, Avon, England
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 326 - 330
SICI:
1078-5884(200110)22:4<326:TSEOIC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; TOTAL ANTIOXIDANT CAPACITY; ISCHEMIA-REPERFUSION INJURY; PERIPHERAL VASCULAR-DISEASE; INFLAMMATORY RESPONSE; HUMAN SERUM; EXERCISE; SURGERY; NEUTROPHILS; ACTIVATION;
Keywords:
intermittent claudication; angioplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, DR 2 Queens Parade,Brandon Hill, Bristol BS1 5XJ, Avon, England 2 Queens Parade,Brandon Hill Bristol Avon England BS1 5XJ gland
Citazione:
D.R. Lewis et al., "The systemic effects of intermittent claudication are reversed by angioplasty", EUR J VAS E, 22(4), 2001, pp. 326-330

Abstract

Introduction: exercise in patients with intermittent claudication causes systemic effects, the consequences of which are unknown. This study investigates whether successful PTA reverses the systemic effects. Patients and Methods: ten patients with IC were recruited prior to PTA. Having emptied their bladders and rested for 1 h, pre-exercise blood and urine samples were collected. Patients underwent treadmill exercise to maximum walking time and blood samples were collected at 10, 20 and 30 min. A second urine sample was collected at 60 min. Total antioxidant capacity (TAC) and von Willebrands Factor (vWF) were measured in blood and albumin/creatinine ratio (ACR) and retinol binding protein/creatinine ratio (RBP/Cr) in urine, Patients were recalled 2 weeks after successful angioplasty and the protocol repeated. Following PTA patients walked for a maximum of 5 min. Results: there was no significant change in vWF. Exercise in claudicants induced a significant increase ill median ACR (pre/post exercise=0.85; p=0.03) and in median RBP/Cr (pre/post exercise=1.8; p=0.04). These changes wereno longer evident after successful PTA. TAC was significantly different before and after angioplasty at all time intervals. Conclusion: successful PTA reverses glomerular effects of exercise in claudicants. Future work should investigate the use of PTA in conjunction with exercise in the treatment Of peripheral vascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 11:56:50