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Titolo:
Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline-induced release of melatonin
Autore:
Mikkelsen, JD; Hauser, F; deLecea, L; Sutcliffe, JG; Kilduff, TS; Calgari, C; Pevet, P; Simonneaux, V;
Indirizzi:
Univ Strasbourg 1, CNRS, UMR 7518, F-67000 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67000 , F-67000 Strasbourg, France H Lundbeck & Co AS, Dept Neurobiol, Copenhagen, Denmark H Lundbeck & Co AS Copenhagen Denmark pt Neurobiol, Copenhagen, Denmark Scripps Clin & Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Dept Biol Sci, Stanford, CA 94305 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 419 - 425
SICI:
0953-816X(200108)14:3<419:H(ITRP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; IMMUNOREACTIVE NERVE-FIBERS; MALE SYRIAN-HAMSTERS; NEUROPEPTIDE-Y; PARAVENTRICULAR NUCLEUS; N-ACETYLTRANSFERASE; MESSENGER-RNA; SPINAL-CORD; NEURONS; HYPOTHALAMUS;
Keywords:
circadian; feeding; HCRT; melatonin; N-acetyltransferase; NAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Simonneaux, V Univ Strasbourg 1, CNRS, UMR 7518, 12 Rue Univ, F-67000 Strasbourg, France Univ Strasbourg 1 12 Rue Univ Strasbourg France F-67000 nce
Citazione:
J.D. Mikkelsen et al., "Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline-induced release of melatonin", EUR J NEURO, 14(3), 2001, pp. 419-425

Abstract

Hypocretin-1 (HCRT-1) and hypocretin 2 (HCRT-2), also known as orexin-A and orexin-B, are two neuropeptides derived from the same precursor. Hypocretinergic neurons have been found exclusively in the hypothalamic dorsolateral area. These neurons are implicated in sleep and feeding through activation of specific G-protein-coupled orexin-1 and orexin-2 receptor (OR-RI and OR-R2). The purpose of this study was to determine the existence of the HCRTpeptides in the central input of the rat pineal gland. Further, OR-R1 and OR-R2 expression was determined in the pineal gland and the effect of HCRT-2 on melatonin synthesis and secretion was analysed in dissociated rat pinealocytes. A large contingent of HCRT-positive nerve fibres and terminals were observed in the epithalamus, many of which entered into the pineal parenchyma. A significant number of nerve fibres endowed with positive boutons were identified in the pineal stalk, though the number of positive fibres decreased along the extension of the stalk. So far, no positive fibres have been found in the superficial pineal gland. RT-PCR analysis revealed the expression of OR-R2 mRNA, whereas OR-R1-receptor mRNA was not detected. When tested alone, HCRT-2 had no effect on secretion of melatonin from cultured rat pinealocytes. However, HCRT-2 partially inhibited (by a maximum of 30%) the beta -adrenergic-induced melatonin secretion. The same effect was seen on activation of N-acetyltransferase activity. The distribution and the large number of HCRT-positive fibres together with the effect on noradrenaline-mediated melatonin release through specific receptors suggests that these peptides may be significant central transmitters in pineal function, probably mediating homeostatic signals to the pineal gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 22:02:22