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Titolo:
Chronic desipramine treatment selectively potentiates somatostatin-induceddopamine release in the nucleus accumbens
Autore:
Pallis, E; Thermos, K; Spyraki, C;
Indirizzi:
Univ Crete, Fac Med, Dept Basic Sci, Pharmacol Lab, Iraklion 71110, Crete,Greece Univ Crete Iraklion Crete Greece 71110 Lab, Iraklion 71110, Crete,Greece
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 14, anno: 2001,
pagine: 763 - 767
SICI:
0953-816X(200108)14:4<763:CDTSPS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT DRUGS; CEREBROSPINAL-FLUID; STRIATAL DOPAMINE; RAT-BRAIN; RECEPTORS; SYSTEM; MICRODIALYSIS; POLYPEPTIDE; AMPHETAMINE; GLUTAMATE;
Keywords:
basal ganglia; microdialysis; neurotransmitter interactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Thermos, K Univ Crete, Fac Med, Dept Basic Sci, Pharmacol Lab, Iraklion 71110, Crete,Greece Univ Crete Iraklion Crete Greece 71110 ion 71110, Crete,Greece
Citazione:
E. Pallis et al., "Chronic desipramine treatment selectively potentiates somatostatin-induceddopamine release in the nucleus accumbens", EUR J NEURO, 14(4), 2001, pp. 763-767

Abstract

Dopamine and somatostatin have been implicated in the pathophysiology of depression. We have employed in vivo microdialysis to investigate the regulation of dopamine release by somatostatin in the nucleus accumbens and the striatum of awake, freely moving rats, and to ascertain how this regulation may be affected by desipramine treatment. Somatostatin-14 (10(-4) M) infusion induced an increase in the release of dopamine and a decrease in the release of its metabolites in both the nucleus accumbens (568% of basal) and the striatum (546% of basal). Chronic desipramine treatment resulted in an exaggerated somatostatin-induced increase of dopamine levels, specifically in the nucleus accumbens (3542% compared with 564% of basal in the striatum), whereas acute desipramine treatment had no effect (582% of basal) compared with saline treated rats. Basal concentrations of dopamine and metabolites were not influenced by either chronic or acute treatment of desipramine in either brain area. These results demonstrate that somatostatin regulates dopamine release in the nucleus accumbens and the striatum. Chronic antidepressant treatment influences somatostatin's actions on dopamine function selectively in the nucleus accumbens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:14:59