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Titolo:
Postnatal maternal deprivation produces long-lasting modifications of the stress response, feeding and stress-related behaviour in the rat
Autore:
Penke, Z; Felszeghy, K; Fernette, B; Sage, D; Nyakas, C; Burlet, A;
Indirizzi:
Univ Henri Poincare, Biol Cellulaire Lab, F-54000 Nancy, France Univ HenriPoincare Nancy France F-54000 aire Lab, F-54000 Nancy, France Semmelweis Univ Med, Inst Clin & Expt Lab Med, H-1135 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1135 ed, H-1135 Budapest, Hungary UER Med Nord, INSERM, U501, F-13916 Marseille, France UER Med Nord Marseille France F-13916 M, U501, F-13916 Marseille, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 14, anno: 2001,
pagine: 747 - 755
SICI:
0953-816X(200108)14:4<747:PMDPLM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; INFANT RAT; PRENATAL STRESS; GLUCOCORTICOID RECEPTORS; CORTICOSTERONE SECRETION; DEXAMETHASONE TREATMENT; GENE-EXPRESSION; MESSENGER-RNA; ADULT-RATS;
Keywords:
anxiety; early stress; food intake; hypothalamo-pituitary-adrenal axis; macronutrient preference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Burlet, A Univ Henri Poincare, Biol Cellulaire Lab, 38 Rue Lionnois, F-54000 Nancy, France Univ Henri Poincare 38 Rue Lionnois Nancy France F-54000 France
Citazione:
Z. Penke et al., "Postnatal maternal deprivation produces long-lasting modifications of the stress response, feeding and stress-related behaviour in the rat", EUR J NEURO, 14(4), 2001, pp. 747-755

Abstract

The hypothalamo-pituitary-ad renal (HPA) axis plays a central role both inthe regulation of the stress response, and in the control of feeding behaviour. Sensitivity of the HPA axis to respond to stress varies both during ontogeny and between individuals, and can be altered by neonatal events. Theaim of our experiments was to determine whether early events that affect the HPA axis could also induce persistent modifications in food intake (quantitatively and qualitatively), as well as alterations of anxiety-related behaviour. Twenty-four-hour maternal deprivation was introduced at two different periods of HPA maturation, on day 5 (DEP5) or day 14 (DEP14) after birth. Sequential measurements of plasma levels of adrenocorticotropin hormone (ACTH) and corticosterone showed that this deprivation altered the HPA axisof adults; the response to restraint stress was prolonged in DEP5 and a higher ACTH peak appeared in DEP14. The neonatal stress also produced long-lasting modifications of rat behaviour, as DEP14 adults became more anxious. Standard food intake decreased in both groups of deprived rats. Diet preferences also changed, as carbohydrate intake decreased in DEP5 rats. Corticosteroid receptor binding did not vary in the hippocampus of the deprived rats. The modifications of the stress response and the behaviour parameters could be due to the alteration of corticosteroid receptors in the hypothalamic paraventricular nucleus and/or corticotropin-releasing hormone or vasopressin function, but these parameters have yet to be determined. This early stress paradigm altering feeding behaviour could become an interesting modelfor research into human eating disorders.

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Documento generato il 03/04/20 alle ore 04:29:58