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Titolo:
Methaemoglobin enhances the proliferation of transformed human epithelial cells: a possible outcome of neovascularisation and haemorrhage in tumours?
Autore:
Wen, WN;
Indirizzi:
Natl Taiwan Univ, Coll Med, Inst Biochem, Taipei 100, Taiwan Natl Taiwan Univ Taipei Taiwan 100 Med, Inst Biochem, Taipei 100, Taiwan
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 15, volume: 37, anno: 2001,
pagine: 1921 - 1929
SICI:
0959-8049(200110)37:15<1921:METPOT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE; CARBON-MONOXIDE; FERRITIN SYNTHESIS; HEME OXYGENASE; IRON; ACTIVATION; METALLOPORPHYRINS; ERYTHROCYTE; PORPHYRINS;
Keywords:
neovascularisation; haemorrhage; methaemoglobin; iron; tumour growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Wen, WN Natl Taiwan Univ, Coll Med, Inst Biochem, Taipei 100, Taiwan Natl Taiwan Univ Taipei Taiwan 100 t Biochem, Taipei 100, Taiwan
Citazione:
W.N. Wen, "Methaemoglobin enhances the proliferation of transformed human epithelial cells: a possible outcome of neovascularisation and haemorrhage in tumours?", EUR J CANC, 37(15), 2001, pp. 1921-1929

Abstract

The effect of human methaemoglobin (metHb), possibly derived from extravasated red blood cells in tumours showing neovascularisation and haemorrhage,on the growth of transformed human epithelial cells was investigated. MetHb stimulated the growth of immortalised epithelial cells or transformed cells at precrisis stage (cells have bypassed M1, but not M2, the two mortality checkpoints). The stimulatory effect was due to the release of haemin from metHb that was isolated by a Sephadex column and identified by its characteristic light absorption spectrum. Although all the degradation products of haemin are currently known to be physiologically significant, only ferriciron derived from metHb or haemin could stimulate cell growth. High concentrations of metHb or haemin inhibited cell growth possibly due to the generation of high concentrations of bilirubin. However, bilirubin formed in thecells of human body is known to be transported to the liver for further processing and excretion. Haemoglobin oxidised to where tumours show neovascularisation and haemorrhage likely contributes significantly to the increased proliferation of cancerous cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:43:53