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Titolo:
Second primary neoplasms after 19281 endocrine gland tumours: aetiologicallinks?
Autore:
Hemminki, K; Jiang, Y;
Indirizzi:
Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 Biosci, S-14157 Huddinge, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 15, volume: 37, anno: 2001,
pagine: 1886 - 1894
SICI:
0959-8049(200110)37:15<1886:SPNA1E>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILY CANCER DATABASE; CARCINOID-TUMORS; THYROID-CANCER; POPULATION; RISKS;
Keywords:
thyroid cancer; adrenal tumours; parathyroid tumours; pituitary tumours; familial cancer; multiple endocrine neoplasia; meningioma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hemminki, K Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 157 Huddinge, Sweden
Citazione:
K. Hemminki e Y. Jiang, "Second primary neoplasms after 19281 endocrine gland tumours: aetiologicallinks?", EUR J CANC, 37(15), 2001, pp. 1886-1894

Abstract

The nationwide Swedish Family-Cancer Database of 9.6 million individuals was used to analyse the development of second neoplasia after 6909 thyroid and 12697 other endocrine tumours. Tumour cases were retrieved from the Swedish Cancer Registry from 1958 to 1996. The risk of a second endocrine tumour was markedly increased compared with first endocrine tumour; e.g. the standardised incidence ratios (SIRS) were well over 10 for adrenal tumours after thyroid cancer, and vine versa. Familial risks were higher for the development of second compared with first neoplasms, and the SIRS for men were usually higher than those for women. Many increases between different endocrine glands can probably be ascribed to known cancer syndromes. Even cancersat some other sites were increased after the development of primary endocrine tumours. Notably, small intestinal carcinoids were increased after thyroid and other endocrine tumours, and brain menigiomas were increased after parathyroid and pituitary adenomas. These novel associations suggest sharedrisk factors for these sites. However, many endocrine tumours are benign and the diagnosis of the first tumour may increase the likelihood of a second diagnosis. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:51:35