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Titolo:
Reproducibility of the parameters of the on-transient cardiopulmonary responses during moderate exercise in patients with chronic obstructive pulmonary disease
Autore:
Puente-Maestu, L; Sanz, ML; Sanz, P; Nunez, A; Gonzalez, F; Whipp, BJ;
Indirizzi:
Univ Madrid, Hosp Gen Gregorio Maranon, Serv Neumol, Madrid 28007, Spain Univ Madrid Madrid Spain 28007 Maranon, Serv Neumol, Madrid 28007, Spain Hosp Virgen Torre, Serv Neumol, Madrid, Spain Hosp Virgen Torre Madrid Spain Virgen Torre, Serv Neumol, Madrid, Spain Univ London St Georges Hosp, Sch Med, Dept Physiol, London SW17 0RE, England Univ London St Georges Hosp London England SW17 0RE on SW17 0RE, England
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 85, anno: 2001,
pagine: 434 - 441
SICI:
1439-6319(200109)85:5<434:ROTPOT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAS-EXCHANGE KINETICS; LUNG-DISEASE; REHABILITATION; COPD;
Keywords:
chronic obstructive pulmonary disease; oxygen uptake; ventilation; heart rate; carbon dioxide output;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Puente-Maestu, L Univ Madrid, Hosp Gen Gregorio Maranon, Serv Neumol, Doctor Ezquerdo 46, Madrid 28007, Spain Univ Madrid Doctor Ezquerdo 46 Madrid Spain 28007 Spain
Citazione:
L. Puente-Maestu et al., "Reproducibility of the parameters of the on-transient cardiopulmonary responses during moderate exercise in patients with chronic obstructive pulmonary disease", EUR J A PHY, 85(5), 2001, pp. 434-441

Abstract

To be clinically useful as indices reflective of altered physiological function consequent to interventions in patients with chronic obstructive pulmonary disease (COPD). the time constant (tau) and steady-state amplitude ofthe kinetic responses for oxygen uptake ((V)over dotO(2)) carbon dioxide output ((V)over dotCO(2)) ventilation ((V)over dot(E)) and heart rate (HR) have to be appropriately differentiable and reproducible. We therefore assessed the reproducibility of a and steady state amplitude values in 41 patients with severe COPD [mean (SD)] [forced expiratory volume in 1 s=41 (7)% predicted], aged 64 (5) years. Of the total, 6 of the patients (15%) did not produce breath-by-breath data of sufficient quality to warrant kinetic analysis. The remaining 35 patients completed two moderate-intensity 10 min square-wave exercise tests separated by 2 h, both before and after an endurance training programme. Tests were conducted on an electromagnetically-brakedcycle ergometer at an exercise intensity corresponding to 80% of the estimated lactate threshold (theta (La)) or 50% of peak oxygen uptake if theta (La) was insufficiently differentiable. Breath-by-breath measurements of (V)over dotO(2), (V)over dotCO(2), (V)over dot(E) and HR were averaged into 10s bins and the on-transient response kinetics were estimated using a mono-exponential model. Analysing the pre-training and the post-training test 1 and test 2 comparisons together, the test 1 -test 2 differences were not significantly different from 0 for either tau or A. The standard deviation ofthe test 1 -test 2 differences allowed us to define the magnitude of change that would reach statistical significance. For tau, this averaged some 8,10, 11 and 8 s. for (V)over dotO(2), (V)over dotCO(2), (V)over dot(E) and HR, respectively, for a one-tailed paired-comparisons test (i.e. appropriate for assessing hypothesised improvements resulting from an intervention); for a two-tailed comparison, the differences were approximately 2 s greater. The corresponding one-tailed values for A were 100 ml(.)min(-1), 95 ml(.)min(-1). 2.5 1(.)min(-1) and 4 beats(.)min(-) 1, respectively; the two-tailed values were 10%-15% greater. We therefore conclude that both tau and A for moderate-intensity exercise can be reproducibly estimated in patients with COPD when the data set provides a sufficiently large amplitude of response and sufficiently low sample variability to allow appropriate parameter estimation.

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Documento generato il 03/04/20 alle ore 04:27:28