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Titolo:
OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats
Autore:
Kostenuik, PJ; Capparelli, C; Morony, S; Adamu, S; Shimamoto, G; Shen, V; Lacey, DL; Dunstan, CR;
Indirizzi:
Amgen Inc, Dept Pathol Pharmacol, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 armacol, Thousand Oaks, CA 91320 USA Amgen Inc, Dept Proc Dev, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 roc Dev, Thousand Oaks, CA 91320 USA Skeletech, Bothell, WA 98021 USA Skeletech Bothell WA USA 98021Skeletech, Bothell, WA 98021 USA
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 10, volume: 142, anno: 2001,
pagine: 4295 - 4304
SICI:
0013-7227(200110)142:10<4295:OAPHAE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSTEOCLAST DIFFERENTIATION FACTOR; ANTIRESORPTIVE AGENTS ESTROGEN; SYNTHETIC PARATHYROID-HORMONE; TUMOR-NECROSIS-FACTOR; TRABECULAR BONE; CORTICAL BONE; INHIBITORY FACTOR; BIOMECHANICAL COMPETENCE; POSTMENOPAUSAL WOMEN; SEXUALLY MATURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kostenuik, PJ Amgen Inc, Dept Pathol Pharmacol, 1 Amgen Ctr Dr, Thousand Oaks, CA 91320 USA Amgen Inc 1 Amgen Ctr Dr Thousand Oaks CA USA 91320 1320 USA
Citazione:
P.J. Kostenuik et al., "OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats", ENDOCRINOL, 142(10), 2001, pp. 4295-4304

Abstract

PTH is a potent bone anabolic factor, and its combination with antiresorptive agents has been proposed as a therapy for osteoporosis. We tested the effects of PTH, alone and in combination with the novel antiresorptive agentOPG, in a rat model of severe osteopenia. Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age. Rats were untreated for 15 months, at which time ovariectomy had caused significant decreases in bone mineral density in the lumbar vertebrae and femur. Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 mug/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc). Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05). OPG significantly reduced osteoclast surface in the lumbar vertebrae and femur (P < 0.05 vs. sham or ovariectomized), but had no effect on osteoblast surface at either site. Ovariectomy significantly decreased the mechanical strength of the lumbar vertebrae and femur. In the lumbar vertebrae, OPG plus PTH was significantly more effective than PTH alone at reversing ovariectomy-induced deficits in stiffness and elastic modulus. These data suggest that OPG plus PTH represent a potentially useful therapeutic option for patients with severe osteoporosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:26:19